Merck Patent Gmbh

Debregeas Et Associes Pharma

Stanipharm

Histolex

Ethypharm, Inc.

Joel Richard

Frantz Deschamps

Anne-marie De Conti

Richard Aubreton

Olivier Thomas

Pascal Suplie

Catherine Herry

Fabrice Leboeuf

Jennifer Jung

Michel Perrut

Christophe Lebon

Rita Agostinetto

Helen Gabriela Baldascini

Luisa De Angelis

Frédéric Imbs

Anne-Marie De Conti

Jöel Parco Di Villa Grazioli Richard

The present invention relates to a novel method for obtaining a pharmaceutical composition based on modafinil. This method consists of solubilizing S modafinil in a fluid in the supercritical state and then after expansion of said fluid, recovering S modafinil by causing it to be absorbed at the surface by a support appearing as granules. Said fluid may be COor another solvent and the support, anhydrous lactose or mannitol. Application of the pharmaceutical composition in the cases when increased short term alertness and over a short period is required for the consumer of the pharmaceutical composition.

Process for obtaining a modafinil-based pharmaceutical composition, resulting pharmaceutical composition and use thereof

The present invention relates to a method for preparing solid pharmaceutical compositions comprising fine particles of at least one active substance, dispersed on and (or) within a divided solid. This method is characterized in that a solution is formed which comprises at least one active substance in a fluid at supercritical pressure, said solution then being expanded in a chamber under temperature and pressure conditions for which a part of said fluid is in the liquid state at the time of the expansion, said fluid thus expanded being brought into contact with a divided solid in said chamber.

Method for preparing pharmaceutical compositions comprising fine particles of active substance

The invention relates to growth hormone (GH) formulations having sustained-release properties, in particular human growth hormone (hGH) and methods for their preparation. The growth hormone formulations can be manufactured without denaturing of the protein and can conveniently be administrated to the person in need thereof by using a conventional syringe via a needle having a small diameter.

Solid lipid microcapsules containing growth hormone inner core microparticles

A method for preparing a sample consisting of biological tissue in a solid matrix includes steps of: contacting the sample with a first compressed fluid stream wherein the matrix is soluble so as to extract the solid matrix, contacting the sample with a second compressed fluid, adapted to impregnate the tissue with an aqueous or water-soluble substance, evacuating the second compressed fluid gradually and in controlled manner, recovering the sample.

Method for preparing a sample

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Nancy, France

Frantz Deschamps