Cornell University

Frantisek Svec

Jean M Frechet

Vladimir Smigol

Ken Hosoya

Jean Jm Frechet

Eric C Peters

Porous polymer monoliths are made thermally responsive by functionalizing/grafting the pores with thermally responsive polymers and copolymers. Depending on the reaction conditions employed, the grafted polymer can either completely block flow through micrometer-sized pores in the monoliths or control the flow rate through the monoliths. The grafted monoliths are useful as thermal gates, thermal valves, and for isocratic hydrophobic interaction chromatography of proteins.

Thermally responsive polymer monoliths

Porous polymeric matrix materials in the form of an integral body having a property gradient selected from any of pore size distribution, chemical composition or a combination thereof are disclosed along with a process for making the same.

Porous polymeric material with gradients

A method of pore-size selective chemical modification of materials having pores of about 1 to 1,500 nm is disclosed. The resulting novel porous materials are particularly useful as separation media in chromatography, for selective isolation, adsorption and catalysis.

Pore-size selective modification of porous materials

A process for separating small molecules from a sample containing small and large molecules using a porous separation medium having bimodal chemistry wherein the small molecules are first removed is disclosed.

Single column chromatographic determination of small molecules in

A continuous liquid chromatographic column containing a separation medium in the form of a macroporous polymer plug is disclosed. The column possesses numerous advantages over conventional columns which are packed with beads or particles. The plug contains both small pores less than 200 nm in diameter and large pores greater than 600 nm in diameter.

Column with macroporous polymer media

A process for carrying out in a consecutive fashion different modes of chromatographic separation in a liquid chromatography column using a single separation medium is disclosed. Separation media for use in such multimodal separations are also disclosed.

Multimodal chromatographic separation media and process for using same

A process for producing macroporous polymer beads from a multiphase emulsion using soluble polymer particles as the primary porogen is disclosed. The beads produced are of uniform size and shape.

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Ithaca, NY, United States of America

Frantisek Svec