Ceskoslovenska Akademie Ved

Frantisek Sorm

Tomislav Barth

Karel Jost

Joseph H Cort

Zdenko Prochazka

Karel Slama

Alois Piskala

Zdenek Arnold

Miroslav Svoboda

Jiri Zavada

Novel nitrophenyl and halophenyl compounds having a side chain substituted with hydroxy or ether radical useful for insect control.

Phenyl ethers having juvenile hormone activity

Stepwise synthesis in solution and cyclization by means of active esters or another method suitable for peptide bond formation were used to prepare analogues of deamino-vasopressin with the disulphide bridge altered to the thioether group. In sequence position 8 of the peptide chain the analogs differed by the nature of basic amino acid. Typical vasopressin-like activities, mainly antidiuretic, were very high in these analogs; of particular importance will be their haemodynamic activity.

Novel analogs of deamino-vasopressin with a modified disulfide bridge

Process for preparing 2',3',5'-tri-0-acetyl-6-azauridine having the following formula ##SPC1## Which comprises reacting a crude anomeric mixture of methyl D-ribofuranosides having the formula ##SPC2## With anhydrous hydrogen chloride or anhydrous hydrogen bromide in the presence of acetic anhydride and acetic acid to thereby form the corresponding 2,3,5-tri-0-acetyl-D-ribofuranosyl halide having the formula ##SPC3## Wherein X is chloro or bromo, reacting the halide of formula III with 3,5-bis-trimethylsilyloxy-1,2,4-triazine having the following formula ##SPC4## In the presence of an inert solvent and a mercuric halide and recovering the 2',3',5'-tri-0-acetyl-6-azauridine.

Process for preparing 2',3',5'-tri-0-acetyl-6-azauridine

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Frantisek Sorm