Synthon B.v.

Synthon Bct Technologies, LLC

Synthon IP Inc.

Noven Therapeutics, LLC

Sython, B.v.

Frantisek Picha

Jacobus Maria Lemmens

Theodorus H A Peters

Frans Van Dalen

Franciscus B G Benneker

Theodorus Hendricus Antonius Peters

Gerrit Jan Bouke Ettema

Franciscus Bernardus Gemma Benneker

Theodorus Hendricus Antonium Peters

Johannes Jan Platteeuw

Jie Zhu

Rolf Keltjens

Jiri Bartl

Hans Jan Hoorn

Pavel Slanina

Montserrat Gallego Luengo

Inocencia Margallo Lana

Juan Cucala Escoi

Johannes J Platteeuw

Theororus Hendricus Antonius Peters

Gertruda Antonetta Philomina Van Helvoirt

Theororus Hendricus Peters

Jacohus Maria Lemmens

Jacobus T H Van Eupen

Gertruda Antonetta Van Helvoirt

Theodorus Hendricus Peters

Franciscus Bernardus Benneker

Peter F A Bakker

The invention relates to a compound, and pharmaceutically acceptable salts, having the formula I: wherein:

Crystalline paroxetine methane sulfonate

An amantadine salt of montelukast is useful in purification of montelukast or its salts and as a pharmaceutical active ingredient.

Montelukast amantadine salt

The benzene sulfonic acid salts of pramipexole have moderate water solubility and are useful pharmaceutical active agents.

Pramipexole acid addition salts

Water-soluble salts of pioglitazone especially pioglitazone sulfate are useful in pharmaceutical applications.

Pioglitazone salts, such as pioglitazone sulfate, and pharmaceutical compositions and processes using the same

The invention relates to a compound, and pharmaceutically acceptable salts, having the formula I:wherein:

4-phenylpiperidine compounds

Amlodipine aspartate and amlodipine maleamide are used as reference standards or markers in determining the purity of amlodipine maleate substances and products.

Reference standards for determining the purity or stability of amlodipine maleate and processes therefor

Venlafaxine besylate compounds provide certain advantages over venlafaxine hydrochloride and are useful in forming pharmaceutical compositions and n treating venlafaxine-treatable diseases and conditions. Venlafaxine besylate can be easily formulated into an extended release dosage form including a hydrogel tablet as well as other matrix-based tablet compositions. A preferred tablet making process involves hot melt granulation.

Venlafaxine besylate

A compound or composition comprising N-formyl paroxetine of formula (1) is useful as a pharmaceutical and as a synthetic intermediate. The N-formyl paroxetine can be an impurity in paroxetine substances and methods of assaying for such an impurity are also useful.

N-formyl derivatives of paroxetine

The synthesis of paroxetine can be made more convenient by using a solvent system comprising an aliphatic alcohol and a hydrocarbon co-solvent. The solvent system is used particularly in the hydrolysis of paroxetine phenylcarbamate and preferably uses butanol and toluene as the system.

Process for the production of paroxetine

Paroxetine salt compositions having improved stability are formed by controlling the pH to 6.5 or less. The compositions can be made with the aide of water without significant coloration problems. The paroxetine salts include paroxetine hydrochloride salts but preferably use paroxetine sulfonate salts such as paroxetine methane sulfonate.

Paroxetine compositions and processes for making the same

A process for making amlodipine maleate comprises reacting amlodipine or an acid addition salt thereof with maleic acid under an acidic environment to form an amlodipine maleate product. The process allows for the formation of amlodipine maleate substantially free from amlodipine aspartate.

Process for making amlodipine maleate

Lactonization of statins can be achieved using a lactonization agent that forms a hydrated complex with the produced water that is insoluble in the reaction solvent. By binding the produced water in an insoluble complex, the reaction is pulled to the lactone side, using mild conditions in short reactions times and with reduced risk of impurities.

Lactonization process

Amlodipine fumarate salt compounds are useful as calcium channel blockers and in treating or preventing angina or hypertension. The fumarate salts avoid the formation of certain potential impurities that have been found to be associated with amlodipine maleate.

Amlodipine fumarate

Imidazopyridine compounds of the formula 1 are can be made in high purity, e.g. greater than 95% pure, by a process that use a novel intermediate of formula 5:

Imidazopyridine derivatives and process for making them

A process for the production of simvastatin and its analogues that is efficient, economical and convenient involves the use of hydroxyl protected intermediates of formula (III) or (VII). These intermediates allow for direct alkylation of the butyrate side chain followed by deprotection and reformation of the lactone ring.

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Brno, Czechia

Frantisek Picha