Novo Nordisk A/s

Novo Nordish A/s

Frantisek Miksik

Knud Erik Andersen

Rolf Hohlweg

Tine Krogh Jo Slashedrgensen

Zdenek Polivka

Peter Madsen

Uffe Bang Olsen

Karel Sindelar

Alexandra Silhankova

Otylie Konigova

Martina Kovandova

Henrik Sune Andersen

The present invention relates to novel N-substituted amino alcohols, amino acids and acid derivatives thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

Heterocyclic compounds

The present invention relates to novel N-substituted azaheterocyclic carboxcylic acids of the general formula wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides.

N-substituted azaheterocyclic compounds

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Prague, Czechia

Frantisek Miksik