Amphastar Pharmaceuticals, Inc.

Other

Frank Zhishi Xia

Jack Yongfeng Zhang

Mary Ziping Luo

Mary Zi-Ping Luo

Gunther L Maier

Rong Zhou

Denny R S Ko

A pre-filled disposable pipette () consisting of a hollow bulb () dimensioned to enclose a medicinal product. From a lower end () of the bulb () is attached sequentially a medicinal transfer tube () and a medication fill tube (), from where the medicinal product is applied. Between a lower end () of the tube () and an upper end () of the tube () is formed a break-away notch (). When the tube () or the tube () is rotated, the notch () is twisted and breaks-off, thus allowing the medicinal product to flow from the bulb () and be released from the tube (). The pipette () includes a primary grasping tab () attached to an upper end () of the bulb (); a secondary grasping tab () attached to each side of the tube (); and a support tab () attached to each side of the tube (). The invention also discloses several methods for sealing the lower tip () of the medication fill tube ().

Easily sealed and opened pre-filled, disposable pipette

A uniform small particle homogenizer for liquid product comprising a pair of intensifier cylinder pumps ( ) driven by a hydraulic system ( ). The pumps have a power stroke side and a suction stroke side, and a pair of proximity sensors ( ) that interface with each pump to detect forward and rearward movement. A microprocessor ( ) with timing capabilities controls the sequential operation of each pump with the power stroke of each pump timed to alternately produce a flow of the liquid product with a precisely timed flow overlap period from the alternating pumps. Since the power stroke takes a longer time than the suction stroke, the instant each power stroke is started the opposite pump is timed to hesitate and slightly overlap until a constant product flow-rate is produced from the alternating pumps, which eliminates large variances in pressure and therefore achieves uniformity in product particle size.

Uniform small particle homogenizer and homogenizing process

A glass bottle protective enclosure ( ) designed to protect a glass bottle ( ) in the event the bottle is subjected to an impact shock. The enclosure is provided with a leak-proof seal and is particularly adapted for protecting glass bottles ( ) containing toxic injectable medication. The enclosure ( ), which is preferably made from a transparent plastic, consists of a lower bottle container ( ) which includes a base ( ) and a plurality of shock absorbing protrusions ( ), which are located to allow a bottle label to be clearly visible, on the base ( ) is located at least one sensor cavity ( ) into which is inserted an enclosure leakage sensor ( ) consisting of either a water soluble sensor ( ) or an electronic sensor ( ). Both of which provide an indication if a bottle leakage occurs. To complete the enclosure ( ) the container ( ) includes a threaded bottle container cap ( ) which includes a plurality of cap shock absorbing protrusions ( ).

Glass bottle protective enclosure

A controlled medicament security enclosure system that houses liquid filled reservoirs which consists of a portable enclosure ( ) formed with a top half ( ) and a bottom half ( ) that permanently snap together to form a secure inseparable repository for the reservoirs. Inside the enclosure is at least one glass vial ( ) for storing the liquid medicament with each vial having a sliding piston stopper ( ) within that seals the inside of the vial and slides to maintain the liquid air free regardless of the volume. An adapter socket ( ) is removably attached to the stopper and includes a hollow needle that pierces the stopper and permits a flowpath for the liquid. A flexible outlet tube ( ) along with connectors on each end transmit the medicament to a mechanical drug delivery system that has a peristaltic pump and a control module.

Controlled medicament security enclosure system

An improved pre-filled disposable pipette ( ) consisting of a hollow tube ( ) dimensioned to enclose a medicinal product and having attached a medication transfer tube ( ) from where the pipette is filled and the medicinal product released. The improvement consists in having a primary grasping tab ( ) attached to an upper end ( ) of the bulb ( ); a secondary grasping tab ( ) attached to each side of the tube ( ); and a support tab ( ) also attached to each side of the tube ( ) near the lower end ( ) of the tube ( ). The primary and secondary grasping tabs ( ) allow the pipette ( ) to be conveniently and easily handled without having to grasp the sensitive bulb ( ) or to directly grasp the tube ( ). The support tab ( ) functions to allow the pipette ( ) to be placed on a conveyor rack apparatus ( ) from where the pipette ( ) can be automatically filled and sealed by a cap ( ) or heat applied foil ( ).

Sealable and manipulable pre-filled disposable pipette

A process of bulk filling containers which includes the steps of arranging a number of containers upside down in a tray ( ) that has a raised peripheral lip ( ). This tray full of containers is then placed in a vacuum chamber ( ) which is then evacuated to a predetermined level below atmospheric pressure. Liquid ( ) is then introduced into the tray through a reservoir ( ) and conduit ( ) which penetrates the wall of the vacuum chamber and the vacuum within the chamber is gradually released at a rate that draws the liquid into the containers. At this point in the process unwanted liquid is rinsed away and the tray is removed from the chamber and turned right side up. The final step is to seal the top of the containers with an appropriate cap, barrier, tip or connection. A second embodiment adds a step to the process by positioning the containers upside down in a rack ( ) and positioning the rack directly above the tray containing the liquid. The rack is then lowered until the container necks are immersed in the liquid. The level of liquid is maintained as above and the balance of the process is conducted the same as the preferred embodiment.

Process of bulk filling

A pre-filled disposable pipette for pharmaceutical and cosmetic products which has a hollow, round pipette body ( ). The body consists of a hollow, rigid bulb section ( ) forming a reservoir for storage and dispersion of the liquid pharmaceutical or cosmetic product which is pre-filled within the body. The body ( ) further includes a hollow tubular section ( ) that is smaller in diameter and contiguous with the bulb section, for ease of handling the pipette. The preferred embodiment has a hollow, frangible upper tube ( ) with a distal end that is sealed for introducing air into the body ( ) when the seal is broken, thus releasing the liquid from the tubular section. The liquid is dispensed from the body by breaking the upper tube allowing air to enter the pipette with the liquid flowing by gravity. The second embodiment has a resilient bulb section and omits the upper tube. A tapered section ( ) is added to the tubular section, with a hollow tip ( ) on the end. The liquid is dispensed from the body ( ) by squeezing the bulb. A seal is in contact with the hollow tubular section, or tip, for retaining the liquid within the body and storage, consisting of either a liquid seal ( ) or a resilient cap ( ).

Pre-filled disposable pipettes

A hypodermic needle capping device (10) that attaches to a hypodermic syringe (100). The device (10) consists of two separate elements: the first consists of a collar (12) having integrally attached a snap-lock structure (24) that includes a locking barb (40) and slide member retaining structure (42). The second consists of a slide member (54) which includes a barb receiving and locking slot (58) and a needle point barrier (76). The collar (12) is frictionally inserted over the upper edge (108) of the syringe (100). The slide member (54) is slidably attached to the slide member retaining structure (42) and is designed to be placed in two positions. When the syringe (100) is to be used, the slide member (54) is positioned along the side of the syringe (100). After the syringe has been used, but prior to being discarded, the slide member (54) is single-handedly slid upward until the locking barb (40) is inserted into the slot (58) at which time the slide member (54) is positioned with the syringe needle (104) point adjacent the needle point barrier (76).

Hypodermic needle capping device

A dual water-level toilet flushing apparatus (10) that allows a toilet user to easily and quickly select either a partial or a full toilet flush. The partial flush which is normally preset is recommended for flushing liquid waste while the full flush is recommended for flushing solid waste. The apparatus (10) which is easily installed and requires no modification to the toilet water tank (60) consists of three major elements: an overflow tube sleeve (12) that attaches to an overflow tube (64) and that has swivelly attached the back end of a floating inverted pendulum (20). The front of the pendulum is attached, via a pendulum/flapper valve link (24), to the front of a toilet flapper valve (30) having its back swivelly attached to the bottom of the overflow tube (64). To effect a partial flush, the toilet flush handle (68) is depressed and immediately released; to effect a full flush the handle (60) is depressed and held for a few seconds.

Growing community of inventors

South El Monte, CA, United States of America

Frank Zhishi Xia