Danisco US Inc.

Purac Biochem Bv

Frank Wouter Koopman

Chris Leeflang

Marc Anton Bernhard Kolkman

Hongxian He

Ryan L Frisch

Harald Johan Ruijssenaars

Nick Johannes Petrus Wierckx

Steven D Doig

Adrianus Johannes Jozef Straathof

Dennis De Lange

Johannes Hendrik De Winde

De Johannes Hendrik Winde

The present disclosure is generally related to compositions and methods for obtainingcells/strains having increased protein production capabilities. Certain embodiments of the disclosure are related to genetically modifiedcells/strains derived from parentalcells/strains comprising a variant rghR2 gene.

Compositions and methods for increased protein production in

The instant disclosure is generally related to compositions and methods for obtaining and constructinghost cells (e.g., protein production host cells, cell factories) having increased protein production capabilities. Certain embodiments of the disclosure are directed to efficient genetic modifications ofcells and the subsequent selection of suchcells having increased protein production capabilities. Certain other embodiments of the disclosure are generally related to methods and compositions for producing/obtaining auxotrophiccells, wherein certain other embodiments of the disclosure are directed to methods and compositions for restoring prototrophy in auxotrophiccells, and expressing genes of interest (GOIs) in such restored prototrophycells.

Methods and compositions for efficient genetic modifications ofstrains

Compositions and methods for increased protein production in bacillus licheniformis

The invention relates to a polypeptide having oxidoreductase activity which comprises the amino acid sequence set out in SEQ ID NO: 3 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 4, or a variant polypeptide thereof having 45% or more sequence identity with the sequence of SEQ ID NO: 3. The invention also relates to a process for the production of 2,5-furan-dicarboxylic acid (FDCA) or production of 5-hydroxymethyl-2-furancarboxylic acid (HMF acid).

Polypeptides having oxidoreductase activity and their uses

Growing community of inventors

Utrecht, Netherlands

Frank Wouter Koopman