Raychem Limited

Other

Life Technologies Corporation

Integenx, Inc.

Intellectual Property Law Dept.

Frank W Mercer

Aldrich N Lau

Lanchi P Vo

Timothy D Goodman

Richard C Sovish

Robert H Reamey

Tai Chun Cheng

Achim Karger

Scott Mack

Jen-Kuei Liu

Zbigniew Cichocki

Bharti Solanki

David P Ching

Hans Michael Wenz

Cevat Akin

Robert S Dubrow

Annelise E Barron

James A Rinde

Christian A Debbaut

Keith Dawes

Albert J Highe

Ben F Johnson

Hendrik Graulus

Subbu S Venkatraman

Michael F Froix

Rafael Camargo

Rudolf R Bukownik

Annelise Barron

Michael P Harrold

Gilbert P Amparo

Aldrich NK Lau

Provided herein is an electrophoresis separation medium comprising: (a) a non-crosslinked or sparsely cross-linked polymer or copolymer; (b) one or more denaturant compounds, in an amount sufficient to inhibit re-naturation of single stranded polynucleotides; (c) an aqueous solvent; (d) optionally, a wall-coating material suited to inhibition of electroosmotic flow; and (e) optionally, an organic water miscible solvent such as DMSO or acetonitrile, wherein the electrophoresis separation medium exhibits functional stability for at least seven days at 23° C. Also provided herein are sieving compositions, including polymer-based sieving compositions, for molecular sieving as well as related kits, devices and methods of use. Such compositions can be useful for separation of biomolecules such as nucleic acids, proteins, glycoproteins and glycans.

Compositions, methods, kits and devices for molecular analysis

Provided herein is an electrophoresis separation medium comprising: (a) a non-crosslinked or sparsely cross-linked polymer or copolymer; (b) one or more denaturant compounds, in an amount sufficient to inhibit re-naturation of single stranded polynucleotides; (c) an aqueous solvent; (d) optionally, a wall-coating material suited to inhibition of electroosmotic flow; and (e) optionally, an organic water miscible solvent such as DMSO or acetonitrile, wherein the electrophoresis separation medium exhibits functional stability for at least seven days at 23&#xb0; C. Also provided herein are sieving compositions, including polymer-based sieving compositions, for molecular sieving as well as related kits, devices and methods of use. Such compositions can be useful for separation of biomolecules such as nucleic acids, proteins, glycoproteins and glycans.

A highly thermally conductive but yet highly conformable composition is made from gel filled with alumina. The use of .alpha.-alumina in which at least 10 weight % of the .alpha.-alumina particles have a particle size of at least 74 .mu.m makes possible the high filler levels needed to attain high thermal conductivity, without causing the decrease in elongation and softness normally associated with high filler levels. Further improvements are observed if the .alpha.-alumina and the gel (or precursor thereof) are mixed with a specific energy input of at least 10 Joule/g. The input of such specific energy has the effect making the resulting composition more conformable than it otherwise would be. The composition may be internally supported by a flexible matrix such as a fabric or open-celled foam.

Highly thermally conductive yet highly conformable alumina filled

A liquid crystal device has, as electrooptically active material, a liquid crystal composite including a containment medium, a liquid crystal composition dispersed in the containment medium, and an organotrialkoxysilane additive having the structure ##STR1## in which R.sub.1 and R.sub.2 are independently H, F, Cl, OCH.sub.3, OCH.sub.2 CH.sub.3, or a C.sub.1 to C.sub.8 alkyl, aryl or arylalkyl group; each R.sub.3 is independently a C.sub.1 to C.sub.8 alkyl, aryl, or arylalkyl; m is an integer from 0 to 4; and n is an integer from 2 to 4. The composite can be used for making liquid crystal displays having improved electro-optical properties, in particular a low operating field.

Liquid crystal composite and device comprising same

Highly thermally conductive yet highly comformable alumina filled

The invention provides for a thermoset or thermoplastic gel composition containing a polymer with anhydride groups along the polymer backbone at least at outset of the fabrication process and an extender fluid, optionally including thermally conductive fillers. The gel compositions are useful for sealing wires, vibration dampening, sporting goods, and toys.

Gels from anhydride-containing polymers

Aromatic bistriazene compounds of the formula ##STR1## wherein --R.sub.1, --R.sub.2, --R.sub.3, and --R.sub.4 are independently --H, --C.sub.6 H.sub.5, --C.sub.6 H.sub.4 Y, or C.sub.1 -C.sub.4 alkyl; --R.sub.5 -- is ##STR2## --R.sub.6 is --F, --Cl, --Br, --CH.sub.3, or --CF.sub.3 ; r is 0, 1, 2, 3, or 4; and --Y is halogen, --NO.sub.2, --C.sub.6 H.sub.5, or C.sub.1 -C.sub.4 alkyl. These bistriazene compounds are useful for cross-linking polymers such as poly(imides), poly(aryl ether ketones), poly(aryl ether sulfones), poly(quinolines), poly(quinoxalines), and nonaromatic fluoropolymers having aliphatic C--H groups.

Aromatic bistriazene compounds

A composition having the structure ##STR1## wherein --R' is --F or --Cl, each --R', which may be the same or different, is independently selected from the group consisting of C.sub.1 -C.sub.6 alkyl or hydroxyalkyl moieties and aryl moieties, and n is 1 or 2. These compositions are useful as co-monomers or end-cappers for the introduction of thermally reactive cross-linking sites into polymers.

Compounds having oxadiazole and triazene moieties, crosslinkable

Fluorinated poly(arylene ethers) having a repeat unit such as ##STR1## are useful as dielectric materials in multilayer interconnects in integrated circuit chips and multichip modules and as protective materials for chips.

Crosslinked fluorinated poly(arylene ether)

Fluorinated polyether compositions having reactive end gorups, such as ##STR1## can be crosslinked to produce cured films useful as dielectrics for microelectronic applications. Other reactive end groups such as allyl, benzocyclobutyl, N-phenylmaleimido, alkynylphenyyl, styryl, allylphenyl, cyanophenyl, and triazenophenyl are also suitable.

Crosslinkable fluorinated aromatic ether composition

Bistriazene compounds such as ##STR1## are useful for crosslinking polymers such as poly(imides), poly(aryl ether ketones), poly(aryl ether sulfones), poly(quinolines), poly(quinoxalines), and nonaromatic fluoropolymers having aliphatic C--H groups. Polymers crosslinked with these bistriazene compounds are useful as interlayer insulators in multilayer integrated circuit articles.

Bistriazene compounds and polymeric compositions crosslinked therewith

Crosslinkable fluorinated polyarylene ether composition

A fluorinated poly(naphthyl ether) having a repeat unit of the formula ##STR1## wherein Y is (CF.sub.2).sub.m, ##STR2## m is an integer from 1 to 4, inclusive, and X is S, CO, SO.sub.2, O, P(C.sub.6 H.sub.5), or C(OH)H. Such polymers are useful as low dielectric constant, low moisture absorption insulators for multilayered integrated circuit articles, especially in their crosslinked form.

Fluorinated poly (naphthyl ether)

An electronic article such as a multichip module or an integrated circuit chip has a multilayer interconnect with multiple layers of conductive material and a dielectric material made of a fluorinated poly(arylene ether) having a repeat unit such as ##STR1##

Electronic articles containing a fluorinated poly(arylene ether)

Fluorinated poly(arylene ether)

Growing community of inventors

Belmont, CA, United States of America

Frank W Mercer