Algenol Biotech LLC

Algenol Biofuels, Inc.

Frank Uliczka

Heike Enke

Alexandra Friedrich

Irina Piven

Ulf Dühring

Dan Kramer

Kerstin Baier

Kui Wang

Tuo Shi

Masami Inaba

Ming-De Deng

Kimberly Lynn Anderson

Ulf Duehring

Methods for increasing the genetic stability of genetically enhanced microbial host cells capable of producing a compound of interest are disclosed.

Methods for increasing the stability of production of compounds in microbial host cells

A genetically enhanced cyanobacterial host cell,sp. ABICyanoI, is disclosed. The enhancedsp. ABICyanoI produces a compound or compounds of interest.

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One embodiment of the invention provides a genetically enhancedsp. host cell comprising at least one first recombinant gene encoding a first protein for the production of ethanol under the transcriptional control of a first inducible promoter, having at least 85%, 90% or 95% sequence identity to an endogenous inducible promoter of thesp. host cell.

A cyanobacterial host cell,sp., that harbors at least one recombinant gene for the production of a chemical compounds is provided, as well as vectors derived from an endogenous plasmid isolated from the cell.

A genetically enhanced cyanobacterial host cell,sp. ABICyano1, is disclosed. The enhancedsp. ABICyano1 produces a compound or compounds of interest.

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Berlin, Germany

Frank Uliczka