Nitto-Denko Corporation

Nutriband, Inc.

Passport Technologies, Inc.

4P Therapeutics

Frank Tagliaferri

Alan Smith

David Enscore

Mirek Baudys

David James Enscore

Jeffrey C Gaulding

Steven Paul Damon

Gaurav Tolia

Jonathan Eppstein

Yogi Patel

Stuart McRAE

Shulun Chang

Stuart Mcrae

An abuse deterrent and misuse deterrent transdermal patch comprising aversive agents incorporated in the backing layer of the patch. The aversive agents can exhibit biphasic or sustained kinetics of release with an immediate portion released rapidly and an extended portion released in a prolonged manner when exposed to a dissolution medium. The prolonged aversive agent release provides deterrence against extraction of drug from fresh and used patches and serves to prevent accidental misuse of used patches by children. The abuse deterrent and misuse deterrent patch systems can be used for transdermal delivery of therapeutically active agents and particularly those drugs that are highly prone to abuse such as opiate and opioid analgesics and stimulants.

Abuse and misuse deterrent transdermal systems

Disclosed are a patch, system, and method for delivery of a permeant composition into a subject via at least one formed pathway through a biological membrane of the subject. The patch comprises a matrix, at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the permeant can dissolve in biological moisture received from the subject, and at least one permeability enhancer disposed within the matrix. Also disclosed are systems and methods for delivery of a permeant composition into a subject via at least one formed pathway through a skin layer of the subject.

Permeant delivery system and methods for use thereof

Growing community of inventors

Decatur, GA, United States of America

Frank Tagliaferri