The University of Texas System

Cornell University

Graybug Vision, Inc.

Universitair Medisch Centrum Utrecht

Mireca Medicines Gmbh

Biolog Life Science Institute Gmbh & Co. Kg

Biolog Life Science Institute Forshungslabor Und Biochemica-vertrieb Gmbh

Frank Schwede

Hans-Gottfried Genieser

Andreas Rentsch

Valeria Marigo

Hening Lin

Bryan A Gibson

Per Ekström

W Lee Kraus

John De Koning

Anne Christensen

Francois Paquet-Durand

Hans Gottfired Genieser

Stein Doskeland

Johannes Bos

Hans Gottfried Genieser

Embodiments of the invention are directed to new polymer linked multimeric guanosine-3',5′-cyclic monophosphate (cGMP) analogues that modulate the cGMP-signaling system, preferably having activating properties, and more preferably being activators of cGMP dependent protein kinase (PKG), and related monomeric precursors thereof. The invention is also directed to related monomeric compounds, which may also show modulating activity and/or may serve as monomeric precursors of the multimers. The invention further relates to the use of such compounds as reagents for signal transduction research and as modulators of cyclic nucleotide-regulated binding proteins and isoenzymes thereof, and as ligands for affinity chromatography, for antibody production or for diagnostic applications e.g. on chip surfaces.

Polymer linked multimers of guanosine-3', 5′-cyclic monophosphates

Embodiments of the invention are directed to new equatorially modified polymer linked multimers of guanosine-3', 5&#x2032;-cyclic monophosphate (cGMP) analogues that inhibit the cGMP-signaling system. The invention is also directed to related monomeric compounds, which may serve as monomeric precursors of the multimers, and/or also show itself inhibitory activity and/or impact the inhibitory activity of the related multimers. The invention further relates to the use of such compounds as reagents for signal transduction research and as modulators of cyclic nucleotide-regulated binding proteins and isoenzymes thereof, and as ligands for affinity chromatography, for antibody production or for diagnostic applications, e.g., on chip surfaces.

Equatorially modified polymer linked multimers of guanosine-3', 5&#x2032;-cyclic monophosphates

Cyclic dinucleotides are described, which in contrast to their natural congeners carry lipophilic nucleobases and have higher membrane permeability and increased biological activity.

Cyclic dinucleotides containing benzimidazole, method for the production of same, and use of same to activate stimulator of interferon genes (sting)-dependent signaling pathways

The present disclosure provides NAD analogs of the formula: 

NAD analogs and methods of using said NAD analogs in determining ribosylation of proteins with PARP mutants

The present invention relates to novel compounds for modulating the activity of exchange proteins directly activated by cAMP (Epacs). In particular, the present invention relates to cAMP analogues that specifically modulate the activity of Epacs. Examples of the compounds of the invention are substituted deoxyadenosine-cyclic monosphosphates. The invention further relates to pharmaceutical compositions comprising the novel compounds, and the use of the compounds in the treatment of diseases like cancer, chronic inflammation, thrombosis and/or type-2 diabetes mellitus in humans and/or animals.

Compounds for modulating the activity of exchange proteins directly activated by cAMP (Epacs)

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Bremen, Germany

Frank Schwede