Dogwood Pharmaceuticals, Inc.

Other

Pinnacle Pharmaceuticals, Inc.

Frank Schmidtmann

Robert Douglas Thompson

Anthony Beauglehole

Jayson Michael Rieger

Sidney M Hecht

Guoquan Wang

Noureddine Fahmi

The present invention provides substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters and pharmaceutical compositions containing the same that are selective agonists of Aadenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.

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Provided herein are alkoxy-carbonyl-amino-alkynyl-adenosine compounds and derivatives thereof and pharmaceutical compositions containing the same that are selective agonists of Aadenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.

The present invention provides substituted 8-[6-amino-3-pyridyl]xanthines like the compound shown in the following formula: and pharmaceutical compositions that are selective antagonists of Aadenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.

Substituted 8-[6-amino-3pyridyl]xanthines

The invention provides a new class of antibiotics to which pathogenic bacteria have not been exposed, and thus should not have developed resistance. This new class of antibiotics are derivatives of &#x3b2;-cyclodextrin (&#x3b2;-CD), which is a cyclic molecule comprising seven D-glucose units.

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Charlottesville, VA, United States of America

Frank Schmidtmann