Multi-magnetics Inc.

Fralex Therapeutics, Inc.

Other

The Lawson Research Institute

Frank S Prato

Alex W Thomas

Robert Z Stodilka

R Terry Thompson

Terry R Thompson

Donna E Goldhawk

Kui Yu

Michael A Persinger

D James Koropatnick

Chunsheng Li

Jeff Carson

Kevin White

Diana Wilkinson

Savita Dhanvantari

Neil Gelman

David Hill

Richard L Nicholson

Elena Choleris

Martin I Kavaliers

Brad J Kemp

Cheryl R McCreary

Jean Theberge

Rene Figueredo

Rebecca McGirr

Benoit Lewden

Cheryl R Mccreary

The invention provides an improved modified magnetosome that contains more iron therein with the combination of the expressed genes. This is achieved by co-expression of (a) one or more bacterial magnetotactic genes to amplify iron uptake, compartmentalization and biomineralization in cells, with (b) one or more mammalian iron handling proteins that together augment(s) and/or regulate the cells iron pool. As a result, mammalian cells or bacterial cells that are transfected or transformed, respectively, can be more effectively tracked using various imaging technologies.

Co-expression of magnetotactic bacterial genes and genes encoding iron handling proteins in cells

The invention is the production of magnetosome-like structures in cells. The invention provides in vitro and in vivo diagnostic and therapeutic methods using eukaryotic cells expressing magnetosome-like structures that act as contrast agents.

Magnetosome gene expression in eukaryotic cells

A hybrid medical imaging system comprises a nuclear medicine imaging subsystem for capturing an image of a target region of a subject, a magnetic resonance imaging (MRI) subsystem for capturing an MRI image of the target region based on at least one MRI parameter and processing structure communicating with the subsystems. The processing structure processes the MRI image to estimate attenuation within the target region and uses the estimated attenuation to correct the image captured by the nuclear medicine imaging subsystem.

System and method for correcting attenuation in hybrid medical imaging

An apparatus for quantifying contrast agent behavior of an administrated contrast agent within a region of interest, comprises an imaging device configured to acquire images of a subject and processing structure communicating with the imaging device. The processing structure is configured to process image data of the acquired images to yield a time sequence of images, I(t), at a location (I) outside of the region of interest that detect contrast agent concentration before the contrast agent enters the region of interest and to yield a time sequence of images, J(t), at a location (J) within the region of interest that detect the contrast agent concentration as the contrast agent perfuses the region of interest. The processing structure is further configured to deconvolve I(t) from J(t) to determine a vector describing the time estimate of the impulse response function, R'(t), for the region of interest, where the shape of the vector is constrained using physiologic and physical considerations and I(t)R&#x2032;(t) is the maximum likelihood estimate of J(t), wheredenotes convolution, and configured to determine the behaviour of the contrast agent in the region of interest based on the determined vector.

Method and apparatus for quantifying the behavior of an administered contrast agent

The invention is the novel use of Quantum Dots (QDs) for radiation dosimetry and includes novel dosimetry devices, systems and methods. The devices, systems and methods have use in a variety of dosimetry applications such as personal, environmental and research. The system for detecting doses of ionizing radiation comprises; a matrix comprising a photoluminescent semiconductor nanocrystals; an illumination interface for exposing the matrix to non-ionizing radiation; a response characterization interface for measuring photoluminescence, scatter or the optical density of the matrix and identifying differences in the photoluminescence, scatter or optical density caused by exposure to ionizing radiation; and a readout interface to quantify the photoluminescence or optical density differences as doses of radiation.

System and methods using quantum dots as general dosimeters

The invention is directed to the use of magnetic shielding alone and magnetic shielding combined with magnetic field stimulation in methods for the treatment, diagnosis and assessment of disease, condition, or physical or mental state. The invention also includes portable devices for the shielding of magnetic fields for therapy and treatment of disease, condition, or physical or mental state.

Device for magnetic and electric field shielding

The invention is directed to the use of magnetic field designed pulses for the diagnoses and classification of severity of disease states and disability in humans and animals.

Diagnosis and classification of disease and disability using low frequency magnetic field designed pulses (Cnps)

A method of applying scatter and attenuation correction to emission tomography images of a region of interest of a patient under observation comprises the steps of aligning a three-dimensional computer model representing the density distribution within the region of interest with the emission tomography images. The computer model is created from image data of other subjects thereby to avoid the need to image the subject under observation to create the computer model. Scatter and attenuation correction is applied to the emission tomography images using the aligned computer model as a guide.

Application of scatter and attenuation correction to emission tomography images using inferred anatomy from atlas

An apparatus and method for treating a disorder selected from the group of physiological, neurological and behavioral disorders, the method comprising applying to a subject a specific low frequency pulsed magnetic field (Cnp) having a plurality of intermittent waveforms, for a time effective to produce a desired effect in a target tissue.

Electrotherapy device using low frequency magnetic pulses

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London, Canada

Frank S Prato