Bristol-Myers Squibb Compnay

Frank S Gibson

Jun Li

Joydeep Kant

Susan D Boettger

Jing Liang

Rajendra P Deshpande

Ulhas P Dhokte

Edward J Gublo

Karen L TenHuisen

A process is provided for preparing 4-alkyl- or 4-aryl-oxycarbonyl paclitaxel analogs which includes the steps of converting paclitaxel into a C-7 acylprotected paclitaxel employing an electrophilic protecting group, such as benzoyloxycarbonyl, and converting the C-7 protected analog into the 4-alkyloxycarbonyl or 4-aryloxycarbonyl paclitaxel analog. Novel intermediates produced in the process are also provided.

Process for preparing 4-alkyl- or 4-aryl-oxycarbonyl paclitaxel analogs and novel intermediates

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Pennington, NJ, United States of America

Frank S Gibson