Johannes Gutenberg-universität Mainz

Scv Spezial-chemikalien-vertriebs Gmbh

Telix Pharmaceuticals Limited

Frank Rösch

Ralf Bergmann

Nils Engelbogen

Lukas Greifenstein

David Parker

Bradley Peter Waldron

Carsten Burchardt

Patrick Riss

Dimitry Filosofov

The invention relates to a marking precursor incorporating a chelator or fluorination group for radiolabelling with 44Sc, 47Sc, 55Co, 62Cu, 64Cu, 67Cu, 66Ga, 67Ga, 68Ga, 89Zr, 86Y, 90Y, 90Nb, 99mTc, 111ln, 135Sm, 140Pr, 159Gd, 149Tb, 160Tb, 161Tb, 165Er, 166Dy, 166Ho, 175Yb, 177Lu, 186Re, 188Re, 213Bi and 225Ac or with 18F, 131I or 211At, and one or two biological targeting vectors which are coupled to the chelator or fluorinating group via one or more squaric acid groups.

Marking precursor with squaric acid coupling

The invention relates to a marking precursor incorporating a chelator or fluorination group for radiolabelling withSc,Sc,Co,Cu,Cu,Cu,Ga,Ga,Ga,Zr,Y,Y,Nb,Tc,In,Sm,Pr,Gd,Tb,Tb,Tb,Er,Dy,Ho,Yb,Lu,Re,Re,Bi andAc or withF,I orAt, and one or two biological targeting vectors which are coupled to the chelator or fluorinating group via one or more squaric acid groups.

Labeling precursors with squaric acid coupling

A compound for radio metal complexation includes a chelator and one or more biological targeting vectors TV conjugated to said chelator, wherein the chelator has structure (A) or (B) or (C), based on 1,4-diazepine with groups R, R, R, R, X, X, X. The compound is particularly suited for complexation of radio-isotopic metals, such asGa(III),Ga(III) andGa(III).

Bifunctional chelating agents based on the 1,4-diazepine scaffold (DAZA) for non-invasive molecular imaging

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Zornheim, Germany

Frank Rösch