Anadys Pharmaceuticals, Inc.

Hoffmann-la Roche Inc.

Frank Ruebsam

Chinh Viet Tran

Douglas Eric Murphy

Peter Scott Dragovich

David J Kucera

Stephen Evan Webber

Yuefen Zhou

Liansheng Li

Zhongxiang Sun

Lijian Chen

Martin Tran

Fritz Blatter

Robert Francis Kester

Martin Viertelhaus

Steven Joseph Berthel

Dionisios Vourloumis

Thomas Jay Prins

Ramakanth Sarabu

Alan X Xiang

David Ellis

Peggy A Thompson

David John Kucera

Douglas E Murphy

Martin T Tran

The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I  

5,6-D hydro-1H-pyridin-2-one compounds

The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I wherein and compounds used to synthesize the compounds of Formula I.

5,6-dihydro-1H-pyridin-2-one compounds

The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of formula: wherein R is C-Calkyl or (Aryl)CH-,and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.

The invention is directed to a 5,6-dihydro-1H-pyridin-2-one compound selected from: 

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The invention is directed to [1,2,4]thiadiazine 1,1-dioxide compounds of formula I wherein A is B is and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.

[1,2,4]thiadiazine 1,1-dioxide compounds

The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I whereinX is N, andA is and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.

Disclosed herein are pyrazole glucokinase activators of the formula (I) useful for the treatment of metabolic diseases and disorders, preferably diabetes mellitus.

Pyrazole glucokinase activators

Disclosed herein are pyrazole glucokinase activators of the formula (I): that are useful for the treatment of metabolic diseases and disorders.

Oxime glucokinase activators

The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.

The invention is directed to 4-hydroxy-5,6-dihydro-1H-pyridin-2-one compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus:  

The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating hepatitis C virus infections:  

The invention is directed to pyrro[1,2-b]pyridazinone compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus: wherein Ris selected from Ring A is 5 or 6- membered aryl or heterocyclyl, and the remaining substituents are defined herein.

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San Diego, CA, United States of America

Frank Ruebsam