Fresenius Medical Care Deutschland Gmbh

Fresenius Kabi Deutschland Gmbh

Frank Nocken

Bernd Sundermann

Silke Baasner

Martin Hepper

Hans Peter Leinenbach

Klaus Biemel

Christoph Meyer

Lars Walz

Methods for detecting a starch in a sample are provided. The methods include the steps of initially incubating the sample in the presence of an amylase-containing medium and subsequently subjecting the sample to liquid chromatography mass spectrometry (LC-MS) to detect ions characteristic of the starch in the sample. The amylase-containing medium can include an amylase and blood plasma or the amylase-containing medium can include an amylase and a component selected from the group consisting of about 90-92% water or buffered water, about 8% protein, about 0.9% salt, and/or about 1.1% organic substances. The incubating step can be done in conditions that permit digestion of the starch by the amylase.

Detection of starch levels in biological matrices

The present invention relates to an ex vivo method for increasing the effectiveness of antibodies and Fc&#x3b3; receptor-binding active ingredients, comprising the steps of: a) preparing a blood sample of a patient; b) subjecting the blood sample to an immunoapheresis; c) administering a therapeutically effective antibody or an Fc&#x3b3; receptor-binding active ingredient to the patient.

Methods for increasing the effectiveness of antibodies and/or FCY receptor-binding active ingredients

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Frankfurt-am-Main, Germany

Frank Nocken