Johnson and Johnson Vision Care, Inc.

Other

Johnson & Johnson Vision Products Inc.

Transitions Optical, Inc.

Vistakon, Inc.

Schepens Eye Research

Frank Molock

Shivkumar Mahadevan

Douglas G Vanderlaan

David Curtis Turner

Azaam Alli

James D Ford

Kevin P McCabe

Wenjing Xiao

Osman Rathore

Barry Van Gemert

Ivan M Nunez

Vandeeta Khanolkar

Giancarlo Fruzzetti

David B Knowles

Robert S Ward

Anu Chopra

Jun Deng

Huayun Yu

Diana Zanini

Beon-Kyu Kim

Stephen D Straight

Kathrine Osborn Lorenz

Victor A Montes

Shanger Wang

Yuan Tian

Joseph R Hepting

Nayiby Alvarez

James M Serpilio, Jr

Joseph Hepting

Jason Garner

Xiao Wenjing

Debra Schaumberg

Lenora Copper

Shiv Mahadevan

Kathy Osborn Lorenz

Saadia Rashid

Various non-limiting embodiments of the present disclosure relate to ophthalmic devices comprising photochromic materials comprising a reactive substituent. For example, the present disclosure contemplates ophthalmic devices comprising photochromic materials, such as photochromic naphthopyrans and indeno-fused naphthopyrans having a reactive substituent comprising a reactive moiety linked to the photochromic naphthopyran by one or more linking groups. In certain non-limiting embodiments, the reactive moiety comprises a polymerizable moiety. In other non-limiting embodiments, the reactive moiety comprises a nucleophilic moiety. Other non-limiting embodiments of the present disclosure relate to methods of making the photochromic ophthalmic device, wherein the photochromic ophthalmic devices comprise the photochromic naphthopyrans described herein.

Ophthalmic devices comprising photochromic materials with reactive sub substituents

Ophthalmic compositions and methods of preparing such compositions are disclosed.

Methods for stabilizing oxidatively unstable compositions

The present invention relates to ophthalmic solutions and devices comprising at least one water soluble polymer having a molecular weight of at least about 500,000 Daltons and linear or branched polyether pendant groups having a molecular weight of at least about 300.

Ophthalmic compositions comprising polyether substituted polymers

Ophthalmic devices comprising photochromic materials with reactive substituents

The present invention relates to a process comprising the steps of reacting a substituted epoxide, and preferably a silicone containing substituted epoxide with at least one lithium acrylic acid salt, at least one acrylic acid and optionally at least one inhibitor at a temperature above about 60&#xb0; C. to form a substituted hydroxy acrylate.

Process for the production of bis(trimethylsilyloxy)silylalkylglycerol methacrylates

The present invention relates to biomedical devices, and particularly contact lenses comprising a polymer having entangled therein at least one acyclic polyamide.

Wettable hydrogels comprising acyclic polyamides

The present invention provides a photochromic material which is an indeno-fused naphthopyran having a pi-conjugation extending group bonded to the 11-position of the indeno-fused naphthopyran, the pi-conjugation extending group having at least one pendent halo-substituted group bonded thereto. The pi-conjugation extending group extends the pi-conjugation system of said indeno-fused naphthopyran. The 13-position of the indeno-fused naphthopyran is substantially free of spiro-substituents. The invention further provides photochromic materials of specified structure, photochromic compositions, photochromic articles and optical elements that include the photochromic material.

Photochromic materials having extended pi-conjugated systems and compositions and articles including the same

The present invention relates to a process comprising polymerizing via irradiation from a light source, a reaction mixture comprising at least one monomer and at least one photoinitiator wherein at least about 90% of incident light emitted by the light source is filtered to produce a soluble, high molecular weight polymer.

Process for the synthesis of soluble, high molecular weight polymers

The present invention relates to a process for the purification of silicone containing compounds via supercritical fluid extraction. Specifically, the present invention relates to a process comprising the steps of contacting at least one silicone containing compound with a supercritical fluid having a density of between about 0.2 and about 0.8 g/ml, decreasing said density so that two phases are formed a first phase comprising said at least one silicone containing compound and a second phase comprising at least one impurity and separating said second phase from said first phase.

Purification of silicone containing compounds by supercritical fluid extraction

The invention provides hydrogels for use in the production of biomedical devices. In particular, the invention provides hydrogels formed from siloxane prepolymers and a hydrophilic monomer, which hydrogels are optically transparent.

Optically transparent hydrogels and processes for their production

The present invention relates to a process comprising the steps of reacting in the presence of an epoxide opening catalyst, a substituted epoxide, and preferably a silicone containing substituted epoxide with at least one carboxylic acid and at least one protecting agent to form a vicinal dialkyl ester or a vicinal disilyl ester.

Process for the production of vicinal diesters from epoxides

The present invention relates to a process for producing substituted glycerol acrylates from substituted epoxides. More specifically, the present invention relates to a process comprising the steps of (a) reacting a first reaction mixture comprising substituted epoxide with at least one epoxide opening catalyst and at least one acrylic acid to form a first reaction product comprising between about 60 and about 85 mole % substituted glycerol acrylate and said substituted epoxide; (b) treating said first reaction mixture with a nucleophilic compound to form a second reaction product which is substantially free of said substituted epoxide and which comprises said substituted glycerol acrylate and a nucleophile derivative of said substituted epoxide; and (c) treating said second reaction product to remove said nucleophile derivative and produce substituted glycerol acrylate having less than about 5 weight % difunctional impurities.

Growing community of inventors

Orange Park, FL, United States of America

Frank Molock