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Agence Nationale De Valorisation De La Recherche (anvar)

Carter Wallace, Inc.

The Agence Nationale De Valorisation De Le Recherche

Frank M Berger

Joseph I DeGraw

Howard L Johnson

Louis A Chedid

Edgar Lederer

Jean-Francois Petit

Arlette Adam

David B Reisner

Bernard J Ludwig

Howard Lynn Johnson

Rita Ciorbaru

Mary P Lechevalier

Constantin Bona

Harold M Bates

George M Fukui

Joseph I Degraw

Compounds of the formula: ##STR1## wherein R.sub.1 is at position 4 and either is an alkyl group of 1-6 C or is an --(CH.sub.2).sub.3 -- which is additionally linked to the phenyl at position 3 thereof;

Phenoxy alkanol esters for treatment of allergic conditions

p-Alkyl or cycloalkyl phenoxy alkanols and esters are provided having the structure: ##STR1## in which: R.sub.1 is an alkyl group having from one to six carbon atoms, preferably tertiary, and still more preferably tertiary-butul; or a bivalent cycloalkylene group condensed with the phenyl group at adjacent ring carbons thereof, such as in indane;

P-alkyl phenoxy alkanols for the treatment of allergic conditions

Skin diseases are treated by topical application of p-substituted phenoxy alkanols having the structure: ##STR1## in which: R.sub.1 substituted in ortho, meta or para position is selected from hydrogen, halogen, alkyl having from one to six carbon atoms, preferably para-chlorine or para-tertiary-butyl; and bivalent cycloalkylene condensed with the phenyl group at adjacent ring carbons thereof, such as in indane;

Process for the treatment of the skin to alleviate skin diseases arising

A process is provided for preparing immunological adjuvants (which are unusual in that they do not contain mycolic acids, mycolic acid esters or lipopolysaccharides, and can increase the immune response in animals of soluble and particulate antigens without the presence of oil or oily vehicles, and without inducing adjuvant arthritis or other undesirable side effects) by solvent extraction from a species of Amycolata, a genus of filamentous branching bacteria known as Amycolata, as well as pharmaceutical compositions containing such adjuvants, and a process for increasing the immune response of antigens in animals by administration of such adjuvants.

Immunological adjuvant and process for preparing the same,

p-Allyl or cycloalkyl phenoxy alkanols and esters are provided having the structure: ##STR1## in which: R.sub.1 is an alkyl group having from one to six carbon atoms, preferably tertiary, and still more preferably tertiary-butyl; or a bivalent cycloalkylene group condensed with the phenyl group at adjacent ring carbons thereof, such as in indane;

Treatment of allergic conditions using indanyloxy-alkanol derivatives

p-Alkyl or cycloalkyl phenoxy alkanols and esters are provided having the structure: ##STR1## in which: R.sub.1 is an alkyl group having from one to six carbon atoms, preferably tertiary, and still more preferably tertiary-butyl; or a bivalent cycloalkylene group condensed with the phenyl group at adjacent ring carbons thereof, such as in indane;

P-Alkyl or cycloalkyl phenoxy alkanols and alkanol esters and process

T-Butyl-phenoxy-alkylene esters of benzoic and nicotinic acids,

The present invention relates to novel immunological agents effective as adjuvants for stimulating an immune response to various types of antigens. The adjuvants do not cause objectionable reactions and they are easily purified. The invention additionally relates to a process for producing the novel adjuvants.

Immunological agents

A method for suppressing the release of histamine from sensitized leukocytes in warm blooded animals which comprises administering internally to said animals compounds of the formula: ##STR1## wherein n is a whole integer from 1 to 4; X is halogen and Z is COOH, CH.sub.2 OR or ##STR2## R being a lower alkyl chain of from 1 to 6 carbon atoms and pharmaceutically acceptable salts of those compounds wherein Z is COOH, in sufficient amount to suppress the release of histamine from said cells.

Method for suppressing histamine release

Water-soluble immunological adjuvants, extracted from mycobacteria and nocardia cells, useful for stimulating, in a host, the immune response to various kinds of antigens.

Process for preparing vaccine adjuvant

Analgesic compositions having a remarkably high analgesic activity and a process for obtaining an analgesic effect are provided, in which the active components are dextro-propoxyphene and at least one of certain benzodiazepines. The analgesic activity of these combinations is remarkable, inasmuch as the benzodiazepines when administered separately do not display appreciable analgesic activity, and moreover benzodiazepines that are pharmacologically inert may also be effective in these combinations.

Analgesic compositions comprising dextro-propoxyphene and benzodiazepine

Analgesic compositions having a remarkably high analgesic activity and a process for obtaining an analgesic effect are provided, in which the active components are levopropoxyphene and a benzodiazepine. The analgesic activity of these combinations is remarkable, inasmuch as neither levopropoxyphene nor benzodiazepines when administered separately display analgesic activity.

Analgesic compositions comprising levo-propoxyphene and benzo diazepine

Chemical compounds of the formula: ##STR1## wherein X is hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy, nitro, amino, acetamido, sulfonamido or trifluoromethyl, and each R is selected from the group consisting of hydrogen and lower alkyl. Said compounds have valuable anti-inflammatory activity in standard laboratory animals.

2,3,4,4A-Tetrahydro-10H-1,2-oxazino[3,2-b](1,3)benzoxazin-10-ones

A process is provided for the alleviation of depression by administration of meperidine analogues corresponding to the formula: ##STR1## in which R.sub.1 and R.sub.2 are each lower alkyl or allyl.

Process for the alleviation of depression by administration of

The invention pertains to a water-soluble immunological adjuvant, especially for vaccines. It is obtained by enzymatic treatment of mycobacteria or Nocardia whole cells in aqueous medium and by a recovery from said aqueous medium.

Growing community of inventors

New York, NY, United States of America

Frank M Berger