E. R. Squibb Sons, Inc.

Frank L Weisenborn

Miguel A Ondetti

B Richard Vogt

Ravi K Varma

Jack Bernstein

Rudiger D Haugwitz

David W Cushman

Roland Greenberg

Michael J Antonaccio

Christopher M Cimarusti

Edward W Petrillo, Jr

Seymour D Levine

Frederic P Hauck

Peter C Wade

William A Slusarchyk

Venkatachala L Narayanan

Thomas P Kissick

Edward Meyers

William E Brown

Linda Louise Setescak

The degradation of enkephalins in a mammalian host is inhibited by administration of an enkephalinase enzyme inhibitor of the formula ##STR1##

Enkephalinase inhibitors

Radiolabeled steroid derivatives having the formula ##STR1## wherein St is a des-hydroxy steroid moiety of (i) a hydroxy steroid intended for radioimmunoassay or (ii) a hydroxy containing derivative of a steroid intended for radio-immunoassay, said derivative having a strong affinity for the antibodies of the steroid intended for radioimmunoassay; R is hydrogen or alkyl of 1 to 3 carbon atoms; n is 0, 1, 2, 3 or 4 and the asterisk (*) indicates tagging with a radioisotope, are useful as tracers in radioimmunoassays.

Steroid derivatives and their use in radioimmunoassays

1-Mercaptoacyl proline or pipecolic acid having an azido group in the 4-position inhibits the conversion of angiotensin I to angiotensin II in mammals and is useful for the treatment of hypertension.

4-Azido-1-mercaptoacyl pipecolic acid

1-Mercaptoacyl proline having an azido group in the 4-position inhibits the conversion of angiotensin I to angiotensin II in mammals and is useful for the treatment of hypertension.

4-Azido-1-mercaptoacyl proline

A new antibiotic, designated kristenin, is produced by the microorganism Bacillus subtilis. The antibiotic possesses activity against gram positive bacteria.

Antibiotic kristenin

Radiolabeled steroid derivatives having the formula ##STR1## wherein St is a des-hydroxy steroid moiety of (i) a hydroxy steroid intended for radioimmunoassay or (ii) a hydroxy containing derivative of a steroid intended for radioimmunoassay, said derivative having a strong affinity for the antibodies of the steroid intended for radioimmunoassay; R is hydrogen or alkyl of 1 to 3 carbon atoms; n is 0, 1, 2, 3 or 4 and the asterisk (*) indicates tagging with a radioisotope, are useful as tracers in radioimmunoassays.

New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors. The compounds claimed in this application are those wherein B is indolyl-lower alkylene.

N-[2-(mercaptoalkyl)-3-mercaptoalkanoyl]-l-tryptophanes

Radiolabeled steroid derivatives having the formula ##STR1## wherein St is des-hydroxy steroid moiety of (i) a hydroxy steroid intended for radioimmunoassay or (ii) a hydroxy containing derivative of a steroid intended for radioimmunoassay, said derivative having a strong affinity for the antibodies of the steroid intended for radioimmunoassay; R is hydrogen or alkyl of 1 to 3 carbon atoms; n is 0, 1, 2, 3 or 4 and the asterisk (*) indicates tagging with a radioisotope, are useful as tracers in radioimmunoassays.

Radiolabeled vitamin B.sub.12 derivatives having the formula ##STR1## wherein R is hydrogen or alkyl of 1 to 3 carbon atoms; n is 0, 1, 2, 3 or 4; and the asterisk (*) indicates tagging with a radioisotope, are useful as tracers in radioassays.

Vitamin B.sub.12 derivative suitable for radiolabeling

New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.

Substituted acyl derivatives of amino acids

New selenium containing derivatives of proline and pipecolic acid which have the general formula ##STR1## are useful as hypotensive agents.

Selenium containing derivatives of proline and pipecolic acid

New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotension converting enzyme inhibitors.

Growing community of inventors

Titusville, NJ, United States of America

Frank L Weisenborn