Evonik Operations Gmbh

Frank Jankowitsch

Frank Schneider

Brigitte Bathe

Silke Jerrentrup

Kornelia Voß

strains express modified gluconate repressor proteins GntR1 and GntR2. Thestrains have an increased ability to produce L-lysine compared with an ability of a wildtype strain. The gluconate repressor protein GntR1 includes an amino acid sequence of SEQ ID NO: 9, where the amino acid Arg in position 102 is replaced by the amino acid Glu. The gluconate repressor protein GntR2 includes SEQ ID NO: 10, and its activity is attenuated compared to the activity of the GntR2 repressor protein of the wild-type strain. A method is developed for the fermentative production of L-lysine using suchstrains.

Method for the fermentative production of L-lysine usingstrains expressing modified gluconate repressor proteins GntR1 and GntR2

A microorganism is transformed to be capable of producing guanidinoacetic acid (GAA). A method can be used for the fermentative production of GAA using such a microorganism. A corresponding method can be used for the fermentative production of creatine.

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Sassenberg, Germany

Frank Jankowitsch