Ustav Experimentalni Botaniky Akademie Ved Ceske Republiky

Institute of Experimental Botany, Academy of Sciences of the Czeck Republic

Institute of Experimental Botany, Academy of Sciences of the Czech Republic

Frank J Massino

Miroslav Strnad

Karel Dolezal

Marek Zatloukal

Lukas Spichal

Jiri Voller

Lucie Szucova

René Lenobel

Igor Popa

Stefaan Werbrouck

Jan Holub

Ludek Frohlich

Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts of the general formula are provided wherein Rand Rare as defined in the specification. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like.

6, 9-disubstituted purine derivatives and their use as cosmetics and cosmetic compositions

Novel heterocyclic derivatives based on N-substituted adenine, having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells and methods of their preparation. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.

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Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts of the following general formula are provided wherein R6 and R9 are as defined in the specification. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for application to mammalian cells, and especially human skin cells, in order to improve the cosmetic appearance of the mammalian cells, especially human skin.

6,9-disubstituted purine derivatives and their use as cosmetics and cosmetic compositions

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Napa, CA, United States of America

Frank J Massino