Hewlett-Packard Company

Frank J DeMonte

Mark A Nickerson

John S Poole

Michael S James

Robert C Kirkpatrick

A method for sample preparation in which a sample matrix is formed into a thin film prior to being brought into contact with an extraction solvent such that the surface area contact between the sample matrix and the solvent is maximized and the cross section of the sample matrix and corresponding diffusion path of components of interest is minimized.

Thin film sample preparation

Methods for handling a plurality of sample containers to be processed by an instrument are disclosed. In a preferred embodiment, a retaining device holds the sample containers and is indexed to align one of the sample containers to a position where communication with a sample input port of the instrument is established. A stripper moves a sample container into engagement with the sample port and, most preferably, also urges the sample container into sealing engagement with the sample port. An interference fit created between the stripper an the sample container provides a positive force that permits the sample container to be withdrawn and returned to its initial position. A lower arm assembly is disclosed which acts as a stop relative to the sample container and thus, as the stripper continues to move while the sample container is being withdrawn it overcomes the force of the interference fit and disengages the stripper. The present invention permits a single sample container to be inserted into a thermal zone to reduce the effects of the thermal zone upon samples not being processed. The present invention is also useful for manipulating a plurality of columns such as capillary columns or columns packed with a sorbent.

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West Chester, PA, United States of America

Frank J DeMonte