Mcneil-ppc, Inc.

Warner-lambert Company

Johnson & Johnson Consumer Inc.

Mcneil Ab

Chenango Zero LLC

Nicklasson, Fredrik

Feng Lin

Frank J. Bunick

Frank J Bunick

Joseph R Luber

Harry S Sowden

Leo B Kriksunov

Christopher Szymczak

Christopher E Szymczak

Jen-Chi Chen

Shiuh John Luo

James J Shaw

Der-Yang Lee

Gregory E Koll

Stephen R Hellman

James Schwing

Gerard P McNally

Mamoun M Hussein

David W Wynn

Kristina Thyresson

Katarina Lindell

Stephen Ulrich

Shun Por Li

Roland Olsson

Shun-Por Li

Martin Thomas

Ralph Cifrese

Alan H Moskowitz

Carolina Militescu

Robert H Graf

Ahmed A Soliman

John J Burke

Timothy P Gilmor

Sheryl A Hutchinson

Michelle Papalini

Jen Chi Chen

Hanspeter Naef

Cynthia Gulian

Stephan G Wiet

Stephen J Saldutti

Paul D Bisio

Jeffrey Morrill

Der Yang Lee

Gail K Buehler

Andreas Hugerth

Fredrik Nicklasson

Joe Luber

John Hendenstrom

Gerard P Mcnally

Rolland Olsson

Stephen A Ulrich

David Wynn

Gus B Labella

Gerard Mcnally

Michele Papalini

Walter G Gowan

The present invention features the present invention features a process for making a tablet by compacting a powder blend in a die platen to form a tablet shape, wherein the powder blend includes a pharmaceutically active agent and a water-containing material, and applying energy to the tablet shape for a sufficient period of time to heat the water-containing material within the tablet shape above its dehydration temperature to form the tablet.

Manufacture of tablet in a die utilizing powder blend containing water-containing material

The present invention features the present invention features a machine for the production of a solid dosage form including: (a) a die platen having one or more forming cavities each having an inner wall, a first opening at the surface of one side of the die platen, and a second opening at the surface on the opposite side of the die platen; (b) one or more first forming tools each adapted to move into one of the forming cavities through the first opening of the forming cavity; (c) one or more second forming tools each adapted to move adjacent to one of the second openings or into one of the forming cavities through the second opening of the forming cavity; (d) at least one first RF electrode operably associated with the one or more first forming tools, the one or more second forming tools, or the inner wall of the one or more forming cavities; and (e) at least one second RF electrode operably associated with the one or more first forming tools.

Machine for the manufacture of dosage forms utilizing radiofrequency energy

The present invention features an orally disintegrating dosage form including from about 5% to about 40%, by weight, of at least one hydrated salt and a pharmaceutically active agent, wherein the at least one hydrated salt has a dehydration temperature of from about 20 to about 120 &#xb0; C.

Orally disintegrative dosage form

The present invention features a process for making a tablet by (i) compacting a powder blend in a die to form a tablet shape, wherein the powder blend contains a pharmaceutically active agent and a meltable binder and (ii) applying radiofrequency energy to the tablet shape for a sufficient period of time to soften or melt the binder within said tablet shape to form the tablet.

Manufacture of tablet in a die utilizing radiofrequency energy and meltable binder

The present invention features a process for making a lozenge product including the steps of forming a powder blend containing an amorphous carbohydrate polymer into the desired shape of the lozenge product and applying radiofrequency energy to the shape for a sufficient period of time to soften or melt said amorphous carbohydrate polymer to fuse the shape into said lozenge product.

Manufacture of lozenge product with radiofrequency

The present invention features the present invention features a tablet including at least one pharmaceutically active ingredient, wherein the shape of said tablet includes at least one major face wherein: (i) the peak penetration resistance at the perimeter of said major face of the tablet is at least about 10% greater than the peak penetration resistance at the center of said major face; and (ii) the tablet disintegrates in the mouth when placed on the tongue in less than about 30 seconds, and a machine and method for manufacture of such tablet.

Manufacture of variable density dosage forms utilizing radiofrequency energy

The present invention features a process for making a chewing gum product including the steps of forming a powder blend containing a gum base into the desired shape of the chewing gum product and applying radiofrequency energy to the shape for a sufficient period of time to soften the gum base to fuse the shape into the chewing gum product.

Manufacture of chewing gum product with radiofrequency

The present invention provides an edible dosage form that incorporates optical elements (e.g., printed patterns, microrelief gratings, and/or macrorelief gratings), capable of producing unique optical effects and images in order to enable a user to better identify and differentiate the dosage forms, as well as to improve the detection of counterfeit production thereof, wherein the edible dosage forms may be made in a variety of ways to incorporate the optical elements therein.

Dosage forms having a microreliefed surface and methods and apparatus for their production

A pharmaceutical composition for oral administration comprising a core and a film coating on the core that exhibits enhanced disintegration characteristics is disclosed. The film coating comprises a film forming polymer, an organic solvent, a super-disintegrant and, optionally, an acid labile material.

Fast dissolving/disintegrating coating compositions

The present invention features a method of manufacturing a tablet containing a pharmaceutically active agent by the steps of: (a) adding a powder containing a pharmaceutically-acceptable carrier to a die cavity; (b) injecting a liquid drug composition containing the pharmaceutically active agent into the die cavity such that the liquid drug composition contacts the powder; (c) compressing the combination of the powder and the liquid drug composition within the die cavity to form the tablet; and (d) removing the tablet from the die cavity.

Manufacture of tablet

In one aspect, the present invention features a process for making a tablet including a pharmaceutically active agent wherein the tablet has both an immediate release region and a modified release region. The method includes the steps of: (a) forming a tablet shape including a powder blend containing a pharmaceutically active agent and a thermally-sensitive material; and (b) applying energy in different amounts to different regions of the tablet shape to form the tablet in a manner such that: (i) a first region of the tablet shape is exposed to said energy for a sufficient period of time to melt the thermally-sensitive material within the first region to form said modified release region of said tablet; and (ii) a second region of said tablet shape is not so exposed to the energy such that said second region forms the immediate release region of said tablet.

Manufacture of tablet having immediate release region and sustained release region

A method of administering non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, is provided. The inventive dosage forms provide an initial release of the NSAID and a second sustained release of NSAID, preferably in a single dosing step.

Immediate release and sustained release ibuprofen dosing regimen

A method for reducing the friability of soft substrates by applying an effective amount of a water soluble, polymeric dispersion to at least a portion of a treatment surface of the substrate, such that less than about 90% of the exterior surface has the dispersion applied thereto.

Method of administering a pharmaceutical active ingredient

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Randolph, NJ, United States of America

Frank J Bunick