Mycogen Corporation

Pfenex Inc.

Dow Agrosciences LLC

Research Corporation Technologies, Inc.

Phillips Petroleum Company

Dow Global Technolgoies LLC

Charles H. Squires

Diane M. Retallack

David C. Watkins

Frank H. Gaertner

Robert Shutter

Stacey Lynn Lee

Frank H Gaertner

Diane M Retallack

David K Watkins

Charles H Squires

George E Schwab

August J Sick

Mark Thompson

Kenneth Edwin Narva

Jewel M Payne

H Ernest Schnepf

Michael Miller Harpold

David W Stroman

David H Rammler

George G Soares

Mary J Hagenson

David L Edwards

Ronald D Klein

Kathryn A Barr

David C Watkins

Mary Jane Hagenson

The invention is a process for improved production of a recombinant mammalian protein by expression in a Pseudomonad, particularly in aorganism. The process improves production of mammalian proteins, particularly human or human-derived proteins, over known expression systems such asin comparable circumstances. Processes for improved production of isolated mammalian, particularly human, proteins are provided.

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The invention is a process for improved production of a recombinant mammalian protein by expression in a Pseudomonad, particularly in aorganism. The process improves production of mammalian proteins, particularly human or human-derived proteins, over known expression systems such asin comparable circumstances Processes for improved production of isolated mammalian, particularly human, proteins are provided.

The present invention provides active cytokine and/or chemokine compositions, as well as inexpensive means for the production, amended-cell encasement of active cytokine and/or chemokine compositions, processing, and delivery of active cytokine and/or chemokine compositions. The subject invention also provides methods of treatment and methods of accelerating an immune response comprising the administration of amended recombinant cell (ARC) containing cytokine and/or chemokine compositions to animals or humans.

Amended recombinant cells for the production and delivery of gamma interferon as an antiviral agent, adjuvant and vaccine accelerant

Two novel linear DNA plasmids are described. Also, novel fragments of the plasmids containing the autonomous replication sequence (ARS), and thus capable of self-maintenance as extra chromosomal elements are provided. These novel DNA sequences of the present invention are useful in a vector for self-maintenance in Pichia pastoris and are also useful as plasmid vectors which can be shuttled between yeast and bacteria.

Pichia pastoris linear plasmids and DNA fragments thereof

The invention concerns a novel isolate of Bacillus thuringiensis which has activity against protozoans. Thus, this isolate, designated PS81F, or the purified protein toxin, or inclusion bodies from this isolate, can be used to treat humans and animals hosting a parasitic protozoan. Further, the gene encoding the toxin can be transferred to a suitable host via a biological vector, e.g., a plasmid or virus.

Bacillus thuringiensis anti-giardia treatment

This invention concerns novel gene probes which can be used to identify DNA from Bacillus thuringiensis microbes which encode protein endotoxins. The invention probes greatly facilitate the search for useful microbes hosting genes which encode toxins.

Probes for the identification of Bacillus thuringiensis endotoxin genes

Novel biological pesticides are prepared by introducing into a microorganism the genetic capability to produce a heterologous pesticide, wherein the microorganism is capable of proliferating in the rhizosphere or phylloplane in competition with wild-type microorganisms. A gene capable of expressing a polypeptide is introduced into the microorganism under conditions which allow for stable maintenance and expression of the gene, without significantly diminishing the ability of the microorganism to compete in the environment. Preferred microorganisms provide for the maintenance and protection from degradation of the polypeptide pesticide.

Pseudomas hosts transformed with bacillus endotoxin genes

This invention concerns novel gene probes which can be used to identify DNA from Bacillus thuringiensis microbes which encode insecticidally-active protein endotoxins. The invention probes greatly facilitate the search for useful microbes hosting genes which encode insecticidally-active toxins.

Universal and specific probes for Bacillus thuringiensis endotoxin genes

The subject invention concerns a novel and useful insecticide with activity against insect pests of the order Coleoptera and the order Lepidoptera. Pests in the order Coleoptera do heavy damage to crops, e.g., corn. The insecticide of the subject invention is a novel B. thuringiensis microbe referred to as B.t. MT 104, or mutants thereof. The spores or crystals of this microbe are useful to control coleopteran and lepidopteran pests in various environments.

Novel Bacillus thuringiensis isolate

Growing community of inventors

San Diego, CA, United States of America

Frank H Gaertner