Pierce Biotechnology, Inc.

Dyomics Gmbh

Carl Zeiss Jena Gmbh

Frank G Lehmann

Peter T Czerney

Matthias S Wenzel

Surbhi Desai

Greg Hermanson

Boguslawa Dworecki

Marie Christine Nlend

Bernd G Schweder

Wilhelm G Frank

Suk Hong

Brian David Wolf

Zakir S Murtaza

Boguslawa R Dworecki

Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.

Fluorescent compounds

Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.

Benzocyanine compounds

Cyanine compounds

Compounds used as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.

Benzopyrylium compounds

The invention concerns compounds based on benzoxazoles wherein selected substituents are each a reactive group A bound via a linker L and adapted to covalently bond a compound of the invention to a to-be-marked molecule K, wherein A is an amine, hydroxy or phosphoramidite function, a carboxylic acid, an alkyl or active ester derived therefrom; a carboxylic acid hydrazide; or a carboxylic acid amide where K is a covalently bound component selected from the group haptenes, proteins (antibodies), low molecular weight drug compounds, peptides, nucleotides, nucleosides, DNA oligomers, polymers, and t is from 1 to 10, and L is a linker selected from a group featuring &#x2014;(CH)&#x2014;, &#x2014;[(CH)&#x2014;O]&#x2014;(CH)&#x2014;, &#x2014;NR10-(CH)&#x2014;, &#x2014;O&#x2014;(CH)&#x2014;, &#x2014;S&#x2014;(CH)&#x2014;, &#x2014;NR10-C(O)&#x2014;(CH)&#x2014;, &#x2014;NR10-C(O)&#x2014;O&#x2014;(CH)&#x2014;, &#x2014;NR10-C(O)&#x2014;NR11-(CH)&#x2014; or &#x2014;SO&#x2014;NR10-(CH)&#x2014;, wherein R10 and R11 are each independently hydrogen, alkyl and alkoxy-alkyl (&#x2014;[(CH)&#x2014;O]&#x2014;CH), &#x3c9;-sulfoalkyl (&#x2014;(CH)&#x2014;SO), m represents the numbers of 2-5, p, r and s each independently represent the number of 1-10.

Marker dyes for UV and short wave excitation with high stokes shift based on benzoxazoles

A phosphine derivative of DyLight dyes modified with ethylene glycol or (poly)ethylene glycol groups. In one embodiment, the compounds are useful in chemoselective ligation reactions.

Phosphine derivatives of fluorescent compounds

Growing community of inventors

Jena, Germany

Frank G Lehmann