Johnson and Johnson Vision Care, Inc.

Frank F Molock, Jr

Azaam Alli

Shivkumar Mahadevan

Ture Kindt-Larsen

Donnie Jerome Duis

Kristy L Canavan

Eric R George

Fang Lu

Holly L Grammer

Carrie L Davis

Ranganath Ramakrishnan Raja

Jaqunda Patton

Kathrine Osborn Lorenz

Annabelle Gallois-Bernos

Nayiby Alvarez-Carrigan

Kim Sander Pedersen

James K Young

Brian Pall

The present invention relates to ophthalmic compositions and methods for the treatment of dry eye and other inflammatory ocular conditions. In particular, the present invention relates to a composition comprising an esterified anti-inflammatory lipid mediator, which is an ester of an anti-inflammatory lipid mediator that is a reaction product of the anti-inflammatory lipid mediator and a monohydric alcohol or an amide wherein the majority of the anti-inflammatory lipid mediator is present in an ester form. In this way, the compositions are substantially free of an acid form of the anti-inflammatory lipid mediators. Anti-inflammatory lipid mediators can be selected from the group consisting of polyunsaturated fatty acids (e.g., omega-three and omega-six fatty acids), resolvins or a metabolically stable analog, protectins or a metabolically stable analog, lipoxins or a metabolically stable analog, prostaglandins or a metabolically stable analog, retinoic acids, endocannabinoids, metabolites thereof, and mixtures thereof. This composition can be topically delivered to the ocular surface via a preparation, solution, gel, ointment, and/or strip and/or a contact lens.

Esters for treatment of ocular inflammatory conditions

Disclosed in this specification is a process for manufacturing a thermochromic contact lens. The process includes (1) selecting a photoinitiator that absorbs at a first wavelength and at least one thermochromic dye that displays substantial absorption at the first wavelength when the dye is at a first temperature and exhibits at least an 80% reduction in absorbance at the first wavelength at a second temperature, (2) maintaining the reaction mixture at the second temperature and (3) providing cure light that includes the first wavelength.

Process for manufacture of a thermochromic contact lens material

Ophthalmic devices and methods of treating allergic conjunctivitis are disclosed herein.

Methods and ophthalmic devices used in the treatment of ocular allergies

Growing community of inventors

Birmingham, United Kingdom

Frank F Molock, Jr