Novosom Ag

Marina Biotech, Inc.

Capsulution Pharma Ag

Frank Essler

Steffen Panzner

Gerold Endert

Cornelia Panzner

Stefan Fankhänel

Silke Lutz

Stefan Fankhaenel

Anja Behrens

The invention suggests amphoteric lipids wherein one or more amphoteric groups having an isoelectric point between 4 and 9 are substituted on a membranous or membrane-forming amphiphilic substance, as well as liposomes containing such compounds.

Components for producing amphoteric liposomes

The invention suggests a pH-sensitive cationic lipid with a pKvalue between 3.5 and 8, according to the general formulacation-spacer-Y-spacer-X-lipid,wherein Y and X represent linking groups. Furthermore, liposomes are described, which liposomes include said optionally cationic lipids.

pH-sensitive cationic lipids, and liposomes and nanocapsules containing the same

Amphoteric liposomes are proposed, which comprise positive and negative membrane-based or membrane-forming charge carriers as well as the use of these liposomes.

Amphoteric liposomes and their use

Amphoteric liposomes

A method for the production of nano- or microcapsules having a diameter of from 20 nm to 40 &#x3bc;m is suggested, wherein template particles are supplied in an aqueous medium, electrically recharged with a polyelectrolyte, re-recharged without separation or washing steps using a second polyelectrolyte having a complementary charge with respect to the first polyelectrolyte, and said process is optionally continued with alternately charged polyelectrolytes.

Nanocapsules having a polyelectrolyte envelope

Growing community of inventors

Halle, Germany

Frank Essler