Fraunhofer-gesellschaft Zur Foerderung Der Angewandten Forschung E.v.

Universitat Leipzig

Fim Biotech Gmbh

Frank Emmrich

Stephan Fricke

Nadja Hilger

Steffen Mitzner

Rainer Dallwig

Claus Kerkhoff

Anne Breitruck

Peggy Bodammer

Gerd Kruger

Gerd Krüger

Manja Kamprad

Manuela Ackermann

Anne BREITRÜCK

The present invention relates to, among others, an in vitro method of modifying a cell graft containing immune cells comprising the steps of incubating a cell graft containing immune cells with an anti CD4 antibody wherein said incubating is carried out for from 1 minute to 7 days, b) removing unbound antibody from said graft; as well as to corresponding modified grafts and uses. The invention further relates to the modification of antibodies reactive to the CD4 human leukocyte antigen to provide anti-CD4 antibodies that have a reduced number of potential T-cell epitopes but retain the ability to bind to CD4, such as to an anti human CD4-antibody comprising a heavy chain immunoglobulin variable domain (VH) and a light chain immunoglobulin variable domain (VL), wherein at least one T cell epitope located outside the CDRs of said immunoglobulin variable domains is removed from said immunoglobulin variable domains. Preferably, the specificity and mode of action of the anti-CD4 antibodies are not affected by the modification(s).

Anti CD4 antibodies to prevent in particular graft-versus-host-disease (GVHD)

Anti CD4 antibodies to prevent in particular graft-versus-host-disease (GvHD)

The invention relates to a clay mineral for use as an agent for reducing the concentration of inorganic phosphate in liquids, in particular in bodily fluids or dialysis liquids, in order to treat hyperphosphatemia, in particular in a renal replacement therapy, wherein before use, the clay mineral is thermally treated at a temperature between 400&#xb0; C. and 800&#xb0; C., preferably between 500&#xb0; C. and 700&#xb0; C., in particular preferably at 550&#xb0; C., over a time period of 60 min to 240 min, preferably 90 min to 180 min, in particular preferably 120 min.

Clay mineral for reducing inorganic phosphates, in particular in renal replacement therapy

In a method for preparing an animal model for the human immune system in a non-human mammal, human stem cells with hematopoietic potential are transplanted into a non-human mammal. The non-human mammal is conditioned with cell culture supernatant of a culture of human cell lines, cells and/or tissue. The cell culture supernatant is derived from cell lines producing cytokines and other molecular mediators.

Animal model for the human immune system, and method for producing the same

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Leipzig, Germany

Frank Emmrich