Bristol-Myers Squibb Compnay

Frank D Yocca

Joseph P Yevich

Ronald J Mattson

David W Smith

Jianqing Li

Robert F Mayol

Edward H Ruediger

Andrew D Williams

Herbert L Smith

The S-stereoisomer of 6-hydroxy-buspirone is an effective treatment for anxiety, depression, and other psychogenic disorders. The S-isomer may provide reduced potential for adverse effects and a longer duration of action compared to the racemic mixture and with buspirone.

S-6-hydroxy-buspirone

The R-stereoisomer of 6-hydroxy-buspirone is an effective treatment for anxiety, depression, and other psychogenic disorders. The R-isomer exhibits greater receptor specificity than the S-isomer and should have reduced potential for the adverse effects associated with the racemic mixture and with buspirone.

R-6-hydroxy-buspirone

A series of novel indol-3-ylalkyl derivatives of alkoxypyrimidinylpiperazines are disclosed as Formula I. ##STR1## These compounds are intended to be useful agents for alleviation of vascular headache on the basis of their potent affinity and agonist activity at 5-HT1D binding sites.

Indolylalkyl derivatives of pyrimidinylpiperazine for treating vascular

A method of treatment of anxiety in benzodiazepine-withdrawn patients by administering BMY 14802 or, preferably, the R-(+)- enantiomer to a patient in need of such treatment.

Treatment of anxiety in benzodiazepine-withdrawn patients

Certain 1-indolylalkyl-4-(alkoxypyrimidinyl)piperazines of Formula I are useful antidepressant agents. The ##STR1## substituents R.sup.1, R.sup.2 and R.sup.5 are hydrogen or lower alkyl; R.sup.3 and R.sup.4 are hydrogen, alkyl, alkoxy, alkythio, carboxamido, halo, or trifluoromethyl; R.sup.6 is alkoxy; and n is the integer 2 or 3.

1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines

A series of 1,4-disubstituted piperazine derivatives comprised of indol-3-ylalkyl and substituted pyridin-2-yl substituent groups. These compounds are useful as antidepressant agents.

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Madison, CT, United States of America

Frank D Yocca