Mount Sinai School of Medicine

Other

Frank Carter Bancroft

Catherine L Clelland

Frank Guarnieri

Makiko Fliss

The present invention relates to a stenographic method for concealing coded messages in DNA. The method of the invention comprises concealing a DNA encoded message within a genomic DNA sample followed by further concealment of the DNA sample to a microdot. The present invention further provides a method for the use of genomic steganography to mark and authenticate objects of interest.

DNA-based steganography

The present invention relates to a method for producing a gene expression library enriched for a particular class of genes comprising (i) a nucleic acid preparation step and (ii) a polyclonal antiserum screening step, wherein both steps define the class of genes of interest. The method of the invention, using selection procedures directed not only at the underlying nucleic acid but also a functional attribute of the target class of proteins, may be used to produce gene expression libraries enriched for genes encoding a desired class of proteins, including, but not limited to, secretory proteins, cell cycle associated proteins, proteins defined by a particular subcellular location, tissue specific proteins, infection-related proteins, and non-infectious disease associated proteins.

Procedure for preparing gene expression libraries enriched for secretory

The present invention relates to a DNA-based computer which is able to perm mathematical calculations such as addition as well as logical operations. It is based, at least in part, on the discovery that DNA molecules can be used to perform operations analogous to 'bit-flipping' in computers. This capability, referred to herein as 'molecular bit-flipping', derives from the complementary nature of DNA sequences. According to the present invention, input data are each represented by single-stranded DNA molecules. Complementary DNA sequences are incorporated such that input molecules, which bear a relationship defined by the operation, hybridize and permit one or more template DNA strands to serve as templates for primer extension. Primer extension, in turn, creates a result DNA molecule which represents the output data, and may be read using straightforward molecular biological techniques.

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Huntington, NY, United States of America

Frank Carter Bancroft