Pfizer Corporation

Frank C Sciavolino

Walter P Cullen

Walter D Celmer

John B Routien

Charles E Moppett

James R Hauske

Mark T Jefferson

Mark A Guadliana

Jeffrey L Ives

Acyltripeptides having the formula below, pharmaceutically acceptable salts thereof and intermediates therefor; processes for their preparation and use as immunostimulant and antibacterial agents. ##STR1## wherein R.degree. is C.sub.1-6 alkyl; x is an integer and is 1 to 4.

Acyltripeptide immunostimulants

4'-Epi erythromycin A and 9-dihydro-4'-epi erythromycin A and derivatives thereof as useful antibacterial agents.

4'-Epi erythromycin A and derivatives thereof as useful antibacterial

Antibacterial macrolides derived from 9-dihydro-11,12-O-isopropylidene-erythromycin A and 9-dihydro-11,12-O-isopropylidene-4'-epi-erythromycin A.

9-Dihydro-11,12-ketal derivatives of erythromycin A and epi-erythromycin

Erythromycylamine 11,12-carbonate, its 2'-acetyl-, 2'-propionyl- and 2'-(3-carbethoxypropionyl)-derivatives; N-(carbobenzoxy)-derivatives and pharmaceutically acceptable acid addition salts of said compounds; their use as antibacterial agents; and processes for their preparation.

Erythromycylamine 11,12-carbonate and derivatives thereof

The novel C.sub.8 modified oleandomycin compounds and the processes for their preparation are disclosed.

Semi-synthetic oleandomycin derivatives--C.sub.8 modifications

Semi-synthetic oleandomycin derivatives-C.sub.8 modifications

Semi-synthetic oleandomycin derivatives - C.sub.8 modifications

Derivatives of oleandomycin, erythromycin A and B, erythromycylamine and erythromycin carbonate, having at the 4'-position an acylamido group, their preparation and use as antibacterial agents are described.

4'-Deoxy-4'-acylamido derivatives of oleandomycin, erythromycin and

A series of 4'-deoxy-4'-amino-erythromycin A antibacterial agents and their preparation from erythromycin A via 4'-deoxy-4'-oxo-erythromycin A intermediates.

Semi-synthetic 4'-erythromycin A derivatives

A new polycyclic ether antibiotic with anticoccidial, antimicrobial and growth promotant properties, its production by fermentation and methods for its recovery and purification are described.

Polycyclic ether antibiotic

A series of 4'-deoxy-4'-amino-oleandomycin antibacterial agents and their preparation from semi-synthetic 4'-deoxy-4'-oxo-oleandomycin intermediates.

Growing community of inventors

East Lyme, CT, United States of America

Frank C Sciavolino