Regulus Therapeutics Inc.

Antisense Therapeutics Limited

Ionis Pharmaceuticals, Inc.

Frank C Bennett

Eric E Swayze

Thazha P Prakash

Kenneth W Dobie

James G Karras

George Tachas

Christine Esau

Jeffrey R Crosby

Susan Gregory

Meghdad Rahdar

Scott E Davis

A method for the treatment and/or prophylaxis of an animal having a respiratory disease or condition associated with airway hyperresponsiveness, eosinophilia, neutrophilia, leukocytes or overproduction of mucus and/or with the expression of integrin &#x3b1;4 comprising administering to the animal a composition comprising from. 0.001 to 1000 &#x3bc;g per kg body weight of the animal of an antisense compound targeted to a nucleic acid molecule encoding integrin &#x3b1;4.

Topical administrations of antisense compounds to VLA-4 for the treatment of respiratory conditions

Provided herein are methods for detection of miRNA in a sample. In certain embodiments, the sample comprises RNA and is derived from a cell or tissue. The methods of detection employ a competitor molecule to allow for detection of an miRNA in the presence of an anti-miRNA oligonucleotide.

MicroRNA detection

Growing community of inventors

Carlsbad, CA, United States of America

Frank C Bennett