Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts

Other

Karlsruher Institut Fur Technologie

Deutsches Krebsforschungszentrum

Medigene Ag

Europaisches Laboratorium Fur Molekularbiologie

Pepperprintgmbh (de/de)

Gross, Karl-heinz

Pepperprint Gmbh

Faulstich, Heinz, Dr.

Frank Breitling

Melvyn Little

Iris Klewinghaus

Stefan Dubel

Michael Braunagel

Gerhard Moldenhauer

Annemarie Poustka

Stefan D&uuml;bel

Valentina Bykovskaya

Yi Li

Peter Altevogt

Ulrich Moebius

Sergey Kipriyanov

Stefan Dübel

Daniela Kelm

Sandra Lüttgau

Patrick Fuchs

Heinz Faulstich

Achim Krueger

Sandra Luettgau

Susanne Sebens

Heiner Schaefer

Ulrich Möbius

Sebastian Schillo

Klaus Leibe

Clemens Matthias Von Bojnicic-Kninski

Gerd Moldenhauer

Silke Bärreiter

Felix Löffler

Khashayarsha Khazaie

Karl-Heinz Gross

Stefanie Gotter

Hans-Jurgen Rode

Rainer Saffrich

Clemens Von Bojnicic-Kninski

Roman Popov

Claudia Haas

Schirrmacher Volker

Felix Friedrich Loeffler

Barbara Ridder

Silke Baerreiter

Daniela Silke Althuon

Frieder Märkle

Thorsten Kühlwein

Alexander Nesterov-Mueller

Alexander Nesterov-Müller

Frieder MÄRKLE

Daniela Silke Mattes

Heiner Schäfer

Achim Krüger

The present invention relates to a method of producing an oligomer array. The invention comprises the steps of: providing a substrate with a multitude of recesses; introducing a first particle with a first molecule into a recess; releasing the first molecule from the first particle; binding the first molecule to a second molecule to form an oligomer while immobilizing the second molecule in the recess; optionally repeating the steps, wherein at least one of the first particles and/or the first molecules comprises a detectable marker.

Ultra high-density oligomer arrays and method of production thereof

The present invention relates to a method for combinatorial particle manipulation for producing high-density molecule arrays, and to the high-density molecule arrays obtained therefrom. In particular, the present invention relates to a method for producing high-density molecule arrays, in particular peptide or oligonucleotide arrays, by combinatorial patterning of particles, wherein the patterning is achieved by the selective and direct action of electromagnetic radiation.

Method for combinatorial particle manipulation for producing high-density molecule arrays, in particular peptide arrays, and molecule arrays that can be obtained by means thereof

For the combinatorial synthesis of molecule libraries, substances are embedded in a matrix consisting of a first solvent thereby forming transport units in a solid state of aggregation at a temperature of less than 90&#xb0; C. and wherein after application to a support, the physical environment of the transport units is modified by the application of a physical process such as a laser printer whereby the substances in the transport units are linked to the support.

Method and devices for applying substances to a support, especially monomers for the combinatorial synthesis of molecule libraries

The present invention relates to the anti-L1 monoclonal antibody 9.3 as well as to related antibodies or binding molecules and well as to the uses thereof, especially in tumor treatment.

Treatment of tumors using specific anti-L1 antibody

The invention relates to a method for the production of a protein library, in particular an antibody library, which is highly diverse and for the selection of proteins, in particular antibodies, therefrom.

Method for producing protein libraries and for selecting proteins from said libraries

A phagemid has been constructed that expresses an antibody fused to coliphage pIII protein. The phagemid is suitable for selecting specific antibodies from large gene libraries with small quantities of antigen. The antibody-pIII gene can be strongly repressed, so that it allows antibody libraries to be amplified without the danger of deletion mutants predominating. After induction, large quantities of the fusion protein may be expressed.

Phagemid for antibody screening

Phagemid library for antibody screening

Cell surface protein and effector cell bonding reagent

Recombinant antibodies at the surface of E. coli

Growing community of inventors

Heidelberg, Germany

Frank Breitling