Vertex Pharmaceuticals, Inc.

Françoise Pierard

Jean-Damien Charrier

Tiansheng Wang

Jeremy Green

Damien Fraysse

Juan-Miguel Jimenez

David Bebbington

Guy Brenchley

Julian M Golec

Dean Boyall

Hayley Binch

Alex Aronov

Simon Everitt

Daniel Robinson

Ronald Kengtel

This invention describes novel pyrazole compounds of formula III: wherein Z, Z, and Zare as described in the specification; Q is &#x2014;S&#x2014;, &#x2014;O&#x2014;, &#x2014;N(R)&#x2014;, or &#x2014;CH(R)&#x2014;; Ris T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; and Rand Rare as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

Pyrazole compounds useful as protein kinase inhibitors

This invention describes novel pyrazole compounds of formula II: wherein Zis nitrogen or CR; Q is &#x2014;S&#x2014;, &#x2014;O&#x2014;, &#x2014;N(R)&#x2014;, or &#x2014;CH(R)&#x2014;; Ris T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; and R, R, and Rare as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

Growing community of inventors

Drayton, United Kingdom

Françoise Pierard