Centre National De La Recherche Scientifique

Institut Pasteur

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

François Rougeon

Catherine Rougeot

Pierre Lafaye

Jean-Pierre Bourgeois

Tony Marcel

Bernard Lopez

Pascale Bertrand

Imenne Azzouz-Boubakour

Use of a variable fragment (VHH antibody) of a camelid single-chain antibody for the preparation of a peptide vector for delivering a substance of interest across the blood-brain barrier or into a cell.

VHH antibodies used as peptide vectors for delivering a substance of interest

The invention relates to the field of psychopharmacology. More particularly, the invention relates to the treatment of mental disorders, such as impaired interpersonal and behavioral disorders, including sexual disorders such as M.E.D. and H.S.D.D. The invention provides new therapeutic compositions and methods for treating mental disorders, including M.E.D. and H.S.D.D. The compositions and methods according to the invention provide improved awareness and alertness to environment, improved adaptation to environment and ability to sustain attention, and increased interest in environment and capacity for arousal, without increased aggressiveness.

Therapeutic methods and compositions for the treatment of impaired interpersonal and behavioral disorders

A method for treating or reducing the severity of a disease or disorder mediated by a membrane metallopeptidase by administering to a mammal a SMR1-peptide or a pharmaceutically active amount of a SMR1-peptide.

Therapeutic uses of SMR1 peptides

Growing community of inventors

Sevres, France

François Rougeon