Les Laboratoires Servier

Vernalis &r&d) Ltd.

Intercept Pharmaceuticals, Inc.

Adir Et Compagnie

Les Laboratories Servier

Vernalis Limited

Françoise Perron-Sierra

Roberto Pellicciari

Olivier Geneste

James Brooke Murray

I-Jen Chen

James Edward Paul Davidson

András Kotschy

Zoltán Szlávik

Antimo Gioiello

Szabolcs Sipos

Balázs Bálint

Attila Paczal

Ágnes Proszenyák

Zoltán Szabó

Márton Csékei

Klaus Seedorf

Alain Bruno

Gábor Radics

Antonio Macchiarulo

Ghanem Atassi

Jacques Duhault

Patrick Casara

Levente Ondi

Gordon Tucker

Joseph Espinal

David Billington

Isabelle Picard

Dominique Saint-Dizier

Andras Kotschy

ÁGnes Proszenyák

The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acide conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.

TGR5 modulators and methods of use thereof

The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acid conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.

Compounds of formula (I): wherein R, R, R, R, R, R, X, Y, A, E and n are as defined in the description. Medicinal products containing the same which are useful in treating a condition requiring a pro-apoptotic agent.

Aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them

Compounds of formula (I): wherein R, R, R, R, R, R, R, R, X, A and n are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

Thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them

Vitronectin receptor antagonist bicyclic compounds, preparation method and compositions containing same

A compound selected from those of formula (I): ##STR1## wherein: R.sub.1, R'.sub.1 and R.sub.2 are each selected, independently of the others, from hydrogen and an alkyl radical, the two R.sub.2 groups being in the cis position in relation to the rings,

Naphthalene compounds

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Paris, France

Françoise Perron-Sierra