Université Pierre Et Marie Curie (paris Vi)

Commissariat a L'energie Atomique

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Francoise Ochsenbein

Alain Sanson

Frederic Dolle

Raphael Guerois

Regis Courbeyrette

Albane Gaubert

The present invention relates to peptides capable of inhibiting the formation of the complex between the Asf1 histone chaperone and histones H3-H4, and to the use thereof as a drug, particularly for treating cancer.

Peptides that inhibit the interaction between ASF1 and histones, and use thereof

The present invention relates to a peptide labelled with fluorine-18 for the specific recognition of lipid vectors. The peptide of the invention comprises the following peptide sequence (PI): in which the amino acids J are chosen independently of each other from natural amino acids, or derivatives thereof, in such a manner that at least 50% of them are polar residues chosen from Arg, Asn, Asp, Cys, Gln, Glu, Gly, His, Lys, Orn, Pro, Ser, Thr and Tyr, the amino acids U are chosen from Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr and Val, the amino acid Xis chosen independently of the other amino acids of the sequence from Ala, Asn, Cys, Gln, Gly, His, Ile, Leu, Met, Phe, Ser, Thr, Trp, Tyr and Val, the amino acid Bis chosen independently of the other amino acids of the sequence from Arg, Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr and Val, the amino acid Zis chosen independently of the other amino acids from Asp and Glu, the amino acids Zand Zare chosen independently from Glu, Asp, Lys and Arg, the superscripts of the residues J, Z, U, X and B representing the positions of these amino acids in the said sequence.

Marked peptides having affinity for a phospholipid and uses

The present invention relates to a peptide for the specific recognition of lipid vectors. The peptide of the invention comprises the peptide sequence (I; SEQ ID NO: 15) below: in which the amino acids J are chosen, independently of one another, from essential amino acids, or derivatives thereof, such that at least 50% of them are polar residues chosen from Arg, Asn, Asp, Cys, Gln, Glu, Gly, His, Lys, Orn, Pro, Ser, Thr and Tyr; the amino acids U are chosen, independently of one another, from Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr and Val; the amino acid Xis chosen, independently of the other amino acids of the sequence, from Ala, Asn, Cys, Gln, Gly, His, Ile, Leu, Met, Phe, Ser, Thr, Trp, Tyr and Val; the amino acid Bis chosen, independently of the other amino acids of the sequence, from Arg, Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr and Val; the amino acid Zis chosen, independently of the other amino acids of the sequence, from Asp and Gly; the amino acids Zand Zare chosen from Glu, Asp, Lys or Arg; and the superscripts of the residues J, Z, U, X and B represent the position of these amino acids in said sequence.

Peptides with affinity for a phospholipid and uses

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Gif sur Yvette, France

Francoise Ochsenbein