Pharmindustrie

Pharmuka Laboratoires

Francoise Hodac

Christian L Renault

Claude G Gueremy

Didier Legroux

Jean-Claude Bondiou

Process for the preparation of compounds of the formula: ##STR1## in which X is H, Cl, Br, I or OH, in which 3-methylene quinuclidine is reacted with an aluminum hydride, in an appropriate solvent and in the presence of a catalytic quantity of a halide of a transition metal, the molar ratio ##EQU1## being at least equal to 0.6, the product formed is reacted in situ with an ester, and then the product thus formed is reacted in situ with an electrophilic reactant which is capable of yielding an atom or group X as defined with reference to formula (I). The compounds of formula (I) can be used for the preparation of medicaments.

Process for the preparation of derivatives of quinuclidine substituted

The compounds of the formula: ##STR1## in which Ar is phenyl or phenyl substituted by 1 or 2 alkoxy groups, by a halogen atom or by a trifluoromethyl group are disclosed together with a process for the preparation thereof. These compounds are antidepressants and antiparkinson agents.

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Francoise Hodac