Societe De Conseils De Recherches Et D'applications Scientifiques

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Societe De Conseils De Recherches Et D'applications Scientifiques (s.c.r.a.s.)

Francoise Heymans

Jean-Jacques Godfroid

Pierre Braquet

Eduardo Pirotzky

Georges Dive

Pascal Clayette

Aazdine Lamouri

Nathalie Dereuddre-Bosquet

Marc Martin

Piperazine derivatives inhibiting human immunodeficiency virus replication

This invention relates to piperazine derivatives of the general formula I ##STR1## wherein --(CH.sub.2).sub.n -- represents a straight or branched chain alkyl group having from n=1 to n=20 carbon atoms, and R represents a hydrogen atom, a branched alkyl group, a cycloalkyl group having from 5 to 10 carbon atoms, a phenyl group, optionally substituted by one or several chlorine atoms, methyl or methoxy groups, or straight or branched chain alkenyl groups having from 3 to 11 carbon atoms, to a preparation process of said compounds and to therapeutic compositions containing them as an active ingredient.

2-substituted N,N'-ditrimethoxybenzoyl piperazines and therapeutic

This invention relates to new tetrahydrofurans and tetrahydrothiophenes of the general formula ##STR1## wherein X stands for O or S, .eta. is an integer from 1 to 6, R stands for various hydrocarbon substituents and Z.sup..crclbar. is a pharmaceutically acceptable anion, to a preparation process of said compounds and to therapeutic compositions of matter containing the same.

5-(.omega.-ammonio acyloxy methylene) tetrahydrofurans and

This invention relates to piperazine derivatives having the general formula I: ##STR1## wherein Y stands for ##STR2## and Z represents various substituents, to a preparation process of said compounds and to therapeutic compositions containing them as an active ingredient.

2-methoxycarbonyl substituted N,N'-di-(trimethoxybenzoyl) piperazines,

This invention relates to piperazine derivatives having the general formula I: ##STR1## wherein Y stands for ##STR2## and Z represents various substituents, to be a preparation process of said compounds and to therapeutic compositions containing them as an active ingredient.

2-Carbonyl substituted N,N'-di-(trimethoxygenzoyl)piperazines, process

5-oxy derivatives of tetrahydrofuran

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Francoise Heymans