Sanofi

Sanofi-aventis

Francoise Bono

Marco Baroni

Alain Badorc

Sandrine Delbary-Gossart

Marie-Francoise Bordes

Nathalie Guillo

Valentina Vercesi

Jean-Marc Herbert

Chantal Alcouffe

Gary Mccort

Antoine Alam

Jean-Pierre Maffrand

Olivier Duclos

Jean-Michel Foidart

Gilles Anne-Archard

Pierre Fons

Jean-Marie Rakic

Agnes Noel

Oliver Duclos

Jacob-Alsboek Olsen

FGF receptor agonist compounds corresponding to the general formula: M1-L-M2 are disclosed in which M1 and M2, which may be identical or different, each represent, independently of one another, a monomer unit M, and L represents a linker group, wherein the monomer unit is of the general formula I. 

FGF-receptor agonist dimeric compounds

The disclosure relates to (heterocycle-fused piperidine)-(piperazinyl)-1-alkanone derivatives and (heterocycle-fused pyrrolidine)-(piperazinyl)-1-alkanone derivatives of formula (I): wherein A, W, R2 and n are as defined in the disclosure, to the method of preparation thereof and the therapeutic use thereof.

(Heterocycle/condensed piperidine)-(piperazinyl)-1-alkanone or (heterocycle/condensed pyrrolidine)-(piperazinyl)-1-alkanone derivatives and use thereof as p75 inhibitors

The disclosure relates to (heterocycle-tetrahydropyridine)(piperazinyl)-1-alkanone and (heterocycle-dihydropyrrolidine)(piperazinyl)-1-alkanone derivatives of formula (I): wherein A, B, m, n, W, and R2 are as defined in the disclosure; to the methods of preparing said derivatives, and to the therapeutic uses thereof.

(heterocycle/tetrahydropyridine)-(piperazinyl)-1-alcanone and (heterocycle/dihydropyrrolidine)-(piperazinyl)-1-alcanone derivatives, and use thereof as p75 inhibitors

The invention concerns compounds of formula I, a method for preparing said compounds, pharmaceutical compositions containing same and the therapeutic uses thereof. 

Imidazo[1,5-a]pyridine derivatives, method for preparing same and pharmaceutical compositions containing same

The disclosure relates to method of treating a disease in which VEGFR-3 is involved, comprising administering a therapeutically effective amount of a compound of the formula wherein R, R, R, and Rare as defined in the disclosure, to compositions containing them, to processes for preparing them, and to their use in therapeutics.

Derivatives of 7 alkynyl-1,8 naphthyridones, preparation method thereof and use of same in therapeutics

(Heterocycle/tetrahydropyridine)-(piperazinyl)-1-alcanone and (heterocycle/dihydropyrrolidine)-(piperazinyl)-1-alcanone derivatives, and use thereof as p75 inhibitors

The present invention relates to derivatives of ((phenyl)-3,6-dihydropyridin-1-yl)(bridged piperazinyl)-1-alkanone derivatives and ((phenyl)-2,5-dihydropyrrol-1-yl) (bridged piperazinyl)-1-alkanone corresponding to Formula (I): in which the variables are as defined herein, to the preparation thereof and to the therapeutic use thereof.

Derivatives of (bridged piperazinyl)-1-alkanone and use thereof as p75 inhibitors

The disclosure relates to compounds of formula (I): wherein R, R, R, and Rare as defined in the disclosure, to compositions containing them, to processes for preparing them, and to their use in therapeutics.

Derivatives of 7-alkynyl-1,8-naphthyridones, preparation method thereof and use of same in therapeutics

The present invention relates to derivatives of 4-{2-[phenyl-3,6-dihydropyridin-1-yl]-2-oxoalkyl}-1-piperazin-2-one and 4-{2-[phenyl-2,5-dihydropyrrol-1-yl]-2-oxoalkyl}-1-piperazin-2-one having general formula (I): in which A, B, m, R3 and n are as defined herein. The invention also relates to the preparation thereof and to the therapeutic use thereof.

Derivatives of 2-oxoalkyl-1-piperazin-2-one, preparation method thereof and therapeutic use of same

The present invention thus relates to the use of 1,2,3-substituted indolizine derivatives in the preparation of medicaments of use in the treatment of diseases related to pathological choroidal angiogenesis, which derivatives correspond to the following general formula (I): 

Use of FGF inhibiting substituted 1,2,3 indolizine derivatives in the preparation of medicaments which can be used to treat diseases linked to pathological choroidal angiogenesis

Imidazo[1,5-a] pyridine derivatives, method for preparing same and pharmaceutical compositions containing same

The present invention relates to novel 1,2,3-substituted indolizine derivative which are inhibitors of fibroblast growth factors, to methods or preparing such derivatives, to pharmaceutical compositions comprising such derivatives, and to methods of treatment comprising such derivatives.

1,2,3-substituted indolizine derivatives, inhibitors of FGFs, method for preparing them and pharmaceutical compositions containing them

The invention is directed to a compound of formula I, wherein R, R, R, Rand Rare as defined herein, or a pharmaceutically acceptable salt thereof, and its pharmaceutically composition, preparation and uses as an inhibitor of FGFs (fibroblast growth factors).

Substituted indolizine 1,2,3,6,7,8 derivatives, FGFs inhibitors, a method for the preparation thereof and pharmaceutical compositions containing said derivatives

Compounds of formula I or salts thereof: in which

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Toulouse, France

Francoise Bono