L'oreal

Francoise Bernerd

Christine Duval

Claire Marionnet

The present invention concerns a method for determining the state of epidermal differentiation of a human keratinocyte in a sample of human epithelium, comprising determining the level of expression of at least one miRNA selected from hsa-miR-455-3p, hsa-miR-141, hsa-miR-148a, hsa-miR-182, hsa-miR-224, hsa-miR-26a, hsa-miR-26b, hsa-miR-361-5p, hsa-miR-425, hsa-miR-92b, hsa-let-7i, hsa-miR-22, hsa-miR-221, hsa-miR-222, hsa-miR-29a, hsa-miR-29b, hsa-miR-663, hsa-miR-30a and hsa-miR-30c within said keratinocyte and comparing the level of expression of the selected miRNA or miRNAs with the mean level of expression of the selected miRNA or miRNAs in non-differentiated keratinocytes, or in differentiated epidermal keratinocytes, preferably originating from the same strain or from the same population. The present invention also concerns various uses of the method for determining the state of epidermal differentiation as well as pharmaceutical or cosmetic compositions.

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Nice, France

Francoise Bernerd