Centre National De La Recherche Scientifique

Institut Pasteur

Francoise Barre Sinoussi

Luc Montagnier

Pierre Sonigo

Marc Alizon

Simon Wain-Hobson

Pierre Tiollais

Jean-Claude Chermann

This invention is in the field of lymphadenopathy virus. This invention relates to a diagnostic means and method to detect the presence of DNA, RNA, or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them, and the proteins expressed.

Nucleic acid probe of human immunodeficiency virus type 1 (HIV-1), and a method and kit employing this probe for detecting the presence of nucleic acid of HIV-1

This invention is in the field of lymphadenopathy virus. This invention relates to a diagnostic means and method of detecting lymphadenopathy associated virus or related viruses or DNA pro-viruses with cloned DNA sequences which are hybridizable to genomic RNA and DNA of lymphadenopathy associated virus. It further relates to the cloned DNA sequences and a process for their preparation.

Cloned DNA sequences hybridizable with genomic RNA of lymphadenopathy associated virus (LAV)

The inventors have isolated cloned cDNA encoding the RNA genome of Human Immunodeficiency Virus type 1 (HIV-1). Various clones are described, which encode different regions of the genome, including those regions encoding viral antigens or proteins. Hybridization results indicate the difference between the HIV-1 clones and those of HTLV-I and HTLV-II. The inventors have also produced a restriction map of the entire cloned genomic sequence in order to facilitate further subcloning and using the restriction fragments in other hybridization tests and in methods to express encoded sequences.

HIV-1 DNA fragments that hybridize to genomic HIV-1DNA

Method for detecting human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) activity

Growing community of inventors

Clamart, France

Francoise Barre Sinoussi