Bio-rad Innovations

Bio-rad Pasteur

Centre National De La Recherche Scientifique

Bio-rad Europe Gmbh

Universitè De Montpellier

Francois Yves Rieunier

Isabelle Karine Giuliani

Sylvie Villard-Saussine

Nadine Lambert

Muriel Feyssaguet

Stephane Gadelle

Stephanie Henriot

Bernard Pau

Claude Granier

Jean-Francois Hubert Delagneau

Fabienne Babin

Stephane Jean Xavier Gadelle

Sylvie Marie-France Trinquier

Catherine Christiane Marie Larue

Stéphane Gadelle

Typhaine Dagland

Charles Didier Calzolari

Odile Suzanne Helene Flecheux

The present invention relates to a polypeptide carrying a human BNP(1-32) epitope according to Formula (I): a-R-X-FGRKMDR-X-R-aas well as ligands specific of the FGRKMDR epitope.

BNP (1-32) epitope and antibodies directed against said epitope

The present invention relates to a polypeptide carrying a human BNP(1-32) epitope according to Formula (I): a-R&#x2014;X&#x2014;FGRKMDR&#x2014;X&#x2014;R-aas well as ligands specific of the FGRKMDR epitope.

The invention relates to a method of in-vitro detection of an infection with a hepatitis C virus (HCV) in a biological sample, comprising the simultaneous detection of the HCV capsid protein and of an antibody directed against said capsid protein, said method using, for capturing the anti-capsid antibodies, a peptide comprising an antigenic fragment derived from the truncated HCV capsid. The invention also relates to the peptide for capturing the anti-capsid antibodies and the kits comprising it.

Method for detecting an infection by the hepatitis C virus

The present invention relates to a polypeptide carrying a human BNP(I-32) epitope according to Formula (I): a-R-X-FGRKMDR-X-R-aas well as ligands specific of the FGRKMDR epitope.

BNP(1-32) epitope and antibodies directed against said epitope

The present invention relates to a double-stranded probe intended for the fluorescent detection of at least one single-stranded or double-stranded target nucleic acid, comprising: &#x2014;a first strand of formula X1-(L1)a-S1-S'1-(L&#x2032;1)b-Y1 intended for the detection of a first strand of the target nucleic acid which comprises a sequence of formula T&#x2032;1-T1; &#x2014;a second strand of formula X2-(L2)c-S2-S&#x2032;2-(L&#x2032;2)d-Y2 intended for the detection of a second strand of the target nucleic acid, if present, the second strand of the target nucleic acid comprising a sequence of formula T&#x2032;2-T2; wherein two of X1, X2, Y1, and Y2 represent a fluorescent donor, while the two others represent a fluorescent acceptor, and X1 and Y2 can not both represent a fluorescent donor.

Double-stranded probes for the fluorescent detection of nucleic acids

The invention involves a synthetic peptide derived from HIV-1 virus gp41 having sequence  where Xis F or G, a method of preparing the synthetic peptide, a composition and a kit containing the synthetic peptide, and use of the synthetic peptide in immunoassays for the detection of infections caused by HIV-1 viruses.

Modified HIV-1 group M cyclic gp41 peptides and their use in the detection of anti-HIV-1 antibodies

Synthetic peptides of the monomer type with 13 to 33 amino acids, in linear form or in a form cyclized by means of inter-cysteine disulphide bridges, have the general formula (I):&#x394;-Z-TrpGlyCys-&#x398;-CysTyrThrSer-&#x3a9;&#x2003;&#x2003;(I)wherein &#x394; is a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CHCO&#x2014;) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group, or an amine functional group, Z represents peptide sequence -&#x39e;-Ser-&#x39e;-, -&#x39e;-Gln-&#x39e;-, or -&#x39e;-Asn-&#x39e;-, wherein -&#x39e;represents a peptide sequence of 0 to 9 amino acids and -&#x39e;represents a peptide sequence of 0 to 5 amino acids, &#x398;is -Arg Gly Arg Leu Ile-(SEQ ID NO: 15), -Arg Gly Arg Leu Val-(SEQ ID NO: 16), -Arg Gly Lys Leu Ile-(SEQ ID NO: 17), -Arg Gly Lys Leu Val-(SEQ ID NO: 18), -Lys Gly Arg Leu Ile-(SEQ ID NO: 19), or -Lys Gly Arg Leu Val-(SEQ ID NO: 20), &#x3a9;, attached to the &#x2014;CO&#x2014; group of serine, is a hydroxyl (&#x2014;OH) radical, an amino (&#x2014;NH) radical, an alkoxy radical having 1 to 6 carbon atoms, a peptide sequence of formula Val-&#x3a3;-&#x3a8; wherein &#x3a3; represents a sequence of formula -(AA)-Trp Asn-(AA)-(AA) wherein (AA) represents an amino acid different from lysine, (AA) represents an amino acid, and (AA) is serine or a threonine residue, and &#x3a8;, attached to the &#x2014;CO&#x2014; residue of the free AAamino acid, is OH, NH, or an alkoxy radical having from 1 to 6 carbon atoms, and a peptide sequence of formula -Val-&#x3a8; wherein &#x3a8;, attached to the &#x2014;CO&#x2014; residue of valine, is OH, NH, or an alkoxy radical having from 1 to 6 carbon atoms.

Synthetic peptides useful in biological essays for detecting infections caused by group O HIV-1 viruses

The invention relates to synthetic biepitope compounds which can be used as standards in immunoassays, for the assay of troponin I, method for preparing them, compositions and kits containing such compounds as well as the immunoassay methods using such compounds.

Growing community of inventors

Fontenay le Fleury, France

Francois Yves Rieunier