Centre National De La Recherche Scientifique

Commissariat a L'energie Atomique Et Aux Energies Alternatives

Université Claude Bernard Lyon I

Ecole Normale Superieure Le Lyon

Ecole Normale Superieure De Lyon

François Riobe

Olivier Maury

Eric Girard

Oliver Maury

Sylvain Engilberge

The invention relates to cationic complexes made up of a lanthanide ion Ln3+ and a ligand of formula (I): with X, Y and R1 as defined in claim, and to the salts thereof with an anion, the solvates and hydrates thereof;with the exception of cationic complexes made up of a lanthanide ion Ln3+ and a ligand of one of formulae (I.1) or (I.4) as defined in claim, and the salts, solvates and hydrates thereof. The invention also relates to the use of such a complex or of a cationic complex made up of a lanthanide ion Ln3+ and a ligand of formula (I.1) or (I.4) as defined in claim, or of one of the salts thereof with an anion, the solvates or hydrates thereof, as an aid to the crystallisation of a biological macromolecule, as well as to crystallisation methods and methods for analysing or determining the structure of a biological macromolecule.

Lanthanide complexes for crystallising biological macromolecules and determining the crystallographic structure thereof

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Lyons, France

François Riobe