Paladin Labs Inc.

Paladin Labs (Barbados) Inc.

Paladin Labs Europe Limited

Verlyx Pharma Inc.

Francois Ravenelle

Damon Smith

Vinayak Sant

Miloud Rahmouni

David Lessard

Laibin Luo

Sandra Gori

Pierre Falardeau

Patrick Colin

Dorothee Le Garrec

The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.

Solid formulations of liquid biologically active agents

The present application relates methods and uses of oral diamidines or pharmaceutically acceptable salts thereof for the treatment of liver diseases or conditions.

Uses and methods for the treatment of liver diseases or conditions

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Montreal, Canada

Francois Ravenelle