Hoffmann-la Roche Inc.

Francois Montavon

Milos Suchy

Franz Dorn

Michelangelo Scalone

Urs Schwitter

Olaf Grassmann

Shaoning Wang

Franziska E Rohrer

Bryant E Rossiter

Stefan Abrecht

Andre Bubendorf

Armin Ruf

Regina Moog

Stephan Goetzoe

Felix Roessler

The invention is concerned with (S)-1-{[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethylamino]-acetyl}-pyrrolidine-2-carbonitrile mesylate and crystalline polymorphs of this compound. This compound and its polymorphic forms exhibits superior properties compared to the previously known compounds and can be used as medicament for the treatment of disorders which are associated with DPP-IV.

Salt and polymorphs of a DPPIV inhibitor

There is disclosed a catalytic hydrogenation process resulting in compounds of the formula ##STR1## wherein the dotted line represents a facultative bond, by hydrogenating the compound of the formula ##STR2## in the presence of a platinum or a nickel catalyst.

Hydrogenation process

Novel pyridine and pyrazine derivatives of the formula ##STR1## wherein R.sup.4 is 3-pyridyl, 3-pyridyl-1-oxide, 2-pyrazinyl, 2-pyrazinyl-1-oxide, 2-pyrazinyl-4-oxide or 2-pyrazinyl-1,4-dioxide, and R, R.sup.1, R.sup.2 and R.sup.3 are as hereinafter set forth, processes for their preparation, fungicidal compositions containing said compounds, and methods for the use of such compounds or compositions for combatting fungi in agriculture and in horticulture are disclosed. Novel starting materials and fungicidal active substances of the formula ##STR2## wherein R.sup.4' is 3-pyridyl or 2-pyrazinyl, and R and R.sup.1' as hereinafter set forth, which are used for the preparation of the compounds of formula I, and their N-oxides, as well as fungicidal compositions containing these compounds as the active substance, are also described.

Certain fungicidal alphabenzyl-3-pyridylmethanol, the corresponding

Pyridine derivatives

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Delemont, Switzerland

Francois Montavon