Medarex Inc.

Medisup International, N.v.

Laboratoire European De Biotechnologie S.a.

Francois Meyer

Michael Gerard Tovey

Ivan Plavec

Patrick Benoit

Debborah Maguire

Deborah Maguire

Georges Lutfalla

Ion Gresser

Gilles Uze

Knud Erik Mogensen

Pierre Eid

The invention relates to a monoclonal antibody directed against the human interferon class I receptor (IFN-R) characterized by the following properties: it recognizes the extracellular domain of the human IFN-R, and it has a neutralizing capacity against the biological properties of the human type I-IFN. It further concerns their use for the diagnosis.

Monoclonal antibodies against the interferon receptor, with neutralizing activity against type I interferon

Monoclonal antibodies against the interferon receptor, with neutralizing activity against type 1 interferon

A monoclonal antibody is provided which is directed against the human interferon type I receptor (IFN-R), which recognizes the extracellular domain of the human IFN-R and which has neutralizing capacity against the biological properties of human type I-IFN. Diagnostic and therapeutic applications for the monoclonal antibody also are provided.

Isolated peptide or polypeptide of the extracellular portion of the human interferon receptor (IFN-R).

Water-soluble polypeptides having high affinity for interferons &agr; and &bgr;; DNA sequences and expression cells; a preparation method therefor; drugs; compositions containing same; and uses thereof as a diagnostic agent or for producing antibodies.

Water-soluble polypeptides having a high affinity for &agr; and &bgr; interferons

Monoclonal antibodies against the interferon receptor, with neutralizing

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Paris, France

Francois Meyer