The General Hospital Corporation

Institut National De La Recherche Scientifique

Aptuit (Verona) Srl, an Evotec Company

Francois Lepine

Laurence G Rahme

Daniele Andreotti

Ronald G Tompkins

Carmela Napolitano

Eric Deziel

Gaoping Xiao

Melissa Starkey

Biliana Lesic-Arsic

Damien Maura

Stefano Fontana

Michele Negri

Antonio Felici

The present application provides malonamide compounds, and derivatives thereof (e.g., N-aryl malonamides (NAM), acetamides, oxalamides, and the like), that are useful, for example, for the treatment of acute, chronic/persistent, and/or relapsing infections. Pharmaceutical compositions, methods of treating diseases (e.g., bacterial infections), and methods of reducing bacterial virulence are also provided.

Broad spectrum antivirulence, anti-persistence compounds

Disclosed are methods for identifying candidate compounds for treating, reducing, or preventing a pathogenic infection, the methods including: (a) contacting a pathogenic cell with a candidate compound; and (b) measuring the production of a molecule selected from the group consisting of an 4-hydroxy-2-alkylquinoline (HAQ) molecule, 4-hydroxy-2-heptylquinoline (HHQ) molecule, or a derivative or precursor thereof in the cell, a candidate compound that reduces the production relative to production of the molecule by a cell not contacted with the candidate compound, identifying a candidate compound useful for treating, reducing, or preventing a pathogenic infection.

Methods for identifying candidate compounds for treating, reducing, or preventing pathogenic infections

The present disclosure relates to benzimidazole-benzamide derivatives, and the use thereof, e.g., to treat infections.

Antibiotic tolerance inhibitors

Growing community of inventors

Laval, Canada

Francois Lepine