Les Laboratoires Servier

Les Laboratories Servier

Centre National De La Recherche Scientifique

Commissariat a L'energie Atomique

Les Laboratories Server

François Lefoulon

Sandrine Pedragosa-Moreau

Tony Verbeuren

Michel Wierzbicki

Alain Rupin

Patricia Sansilvestri-Morel

Jérôme Paysant

Sandrine Pedragosa Moreau

Gerard Damien

Yves Rolland

Gordon Tucker

Luc Demuynck

Bernard Marchand

Eric Doris

Marie-Francoise Boussard

Stéphanie Lerondel

Marie-Françoise Boussard

Francisco Moris Varas

Thomas Arnauld

Julien Ogier

Hubert Grandon

Jean-Marie Delbos

Guillaume Reveillon

Alain Lepape

Marie Françoise Boussard

Process for the enzymatic synthesis of the compound of formula (I): wherein Rrepresents a hydrogen atom or an alkyl group. Application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

Process for the enzymatic synthesis of (7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid or esters thereof, and application in the synthesis of ivabradine and salts thereof

Process for the enzymatic synthesis of the compound of formula (I): comprising enantioselective enzymatic hydrolysis of the nitrile of formula (IV): using the nitrilase ofof EMBL accession number EF467367.1, and the application of such a process in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

Process for the enzymatic synthesis of (7S)-3,4-dimethoxybicyclo[4.2.0]OCTA-1,3,5-triene-7-carboxylic acid and application in the synthesis of ivabradine and salts thereof

Compounds of formula (I) in which: &#x3e;R is a linear or branched (C-C) alkyl, &#x3e;L is a spacer group, &#x3e;A is a diagnostic agent, and &#x3e;m is equal to 1 or 2.

Imaging agents, process for the preparation thereof and pharmaceutical compositions containing same

Process for the enzymatic synthesis of the compound of formula (I), (7S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)N-methyl methanamine: and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

Process for the enzymatic synthesis of (7S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl) N-methyl methanamine, and application in the synthesis of ivabradine and salts thereof

Polymerized micelles comprising polymerized amphiphilic molecules obtained starting from amphiphilic molecules having one or two lipid chains each comprising one or two polymerizable moieties and linked to a polar head.

Polymerized micelles

Compounds of formula (I): wherein R, Rand R, which may be the same or different, each represent a hydrogen atom or the group of formula (A):  Medicinal products containing the same which are useful in the prevention and/or treatment of venous diseases and other conditions.

Diosmetin compounds, a process for their preparation and pharmaceutical compositions containing them

Compounds of formula (I): wherein R, Rand R, which may be the same or different, each represent a hydrogen atom or the group of formula (A): Medicinal products containing the same which are useful in the prevention and/or treatment of venous diseases and other conditions.

Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them

Strontium salts of the sulphonic acids of formula (I):A-B&#x2014;SOH&#x2003;&#x2003;(I), Medicinal products containing the same which are useful in the treatment of osteoarthritis and osteoporosis.

Strontium salts of sulphonic acids, a process for their preparation and pharmaceutical compositions containing them

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Orleans, France

François Lefoulon